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Merck
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Key Documents

SML2514

Sigma-Aldrich

Nedaplatin

Sinónimos:

Nedaplatin, Cis-Diammine (Glycolato)Platinum

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About This Item

Fórmula empírica (notación de Hill):
C2H8N2O3Pt
Número de CAS:
Peso molecular:
303.17
UNSPSC Code:
12352200
NACRES:
NA.77

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form

powder

storage temp.

2-8°C

InChI

1S/C2H4O3.2H2N.Pt/c3-1-2(4)5;;;/h3H,1H2,(H,4,5);2*1H2;/q;2*-1;+2

Inchi Key

KLNFSAOEKUDMFA-UHFFFAOYSA-N

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Este artículo
WHA10331551WHA10331456WHA10331556
pore size

15-18 μm (Particle retention)

pore size

20 μm (max.)

pore size

15-18 μm (Particle retention)

pore size

20 μm (max.)

diam.

240 mm

diam.

240 mm

diam.

500 mm

diam.

500 mm

material

cellulose filters (super-refined), circles

material

cellulose filters (super-refined), circles

material

cellulose filters (super-refined), circles

material

cellulose filters (super-refined), circles

parameter

17.5 sec/100 mL speed (Herzberg)

parameter

28 sec/100 mL speed (Herzberg)

parameter

17.5 sec/100 mL speed (Herzberg)

parameter

28 sec/100 mL speed (Herzberg)

packaging

pack of 100

packaging

pack of 50

packaging

pack of 100

packaging

pack of 50

Biochem/physiol Actions

Nedaplatin is a second-generation cisplatin analog with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. Nedplatin is less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1B - Skin Irrit. 2 - Skin Sens. 1B - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Takuma Kagami et al.
BMC cancer, 20(1), 1123-1123 (2020-11-22)
Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this study, we examined the prognostic value of SLFN11 expression in esophageal squamous cell carcinoma
Jun Fu et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 25(4), 1707-1713 (2020-10-26)
To investigate the efficacy and safety of irinotecan combined with nedaplatin in the treatment of small cell lung cancer (SCLC). 64 patients diagnosed with SCLC in our hospital from April 2013 to June 2015 were retrospectively analyzed. Thirty-two patients in
Hongmei Zhang et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 25(1), 80-86 (2020-04-12)
To study the efficacy of bevacizumab combined with nedaplatin in the treatment of ovarian cancer and its effects on tumor markers and immunity of patients. A total of 100 ovarian cancer patients treated in our hospital from January 2015 to
Osamu Maeda et al.
Anticancer research, 40(5), 2497-2507 (2020-05-06)
Spectrin αII contributes to cisplatin and carboplatin resistance in ovarian serous carcinoma cells, and its expression in surgical specimens is a valid predictor of prognosis. We sought to identify effective drugs for spectrin αII-mediated cisplatin-resistant cells. We employed SKOV3 cells
Tomonori Sasahira et al.
International journal of molecular sciences, 21(10) (2020-05-28)
Because oral squamous cell carcinomas (OSCCs) have a high potential for locoregional invasion and nodal metastasis, early detection and treatment are essential. A LAP2, emerin, MAN1 (LEM) domain containing 1 (LEMD1) is associated with local progression, clinical stage, nodal metastasis

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