Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

232120

Sigma-Aldrich

cis-Diammineplatinum(II) dichloride

≥98% (HPLC), solid, anti-neoplastic agent, Calbiochem

Sinónimos:

Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula lineal:
Pt(NH3)2Cl2
Número de CAS:
15663-27-1
MDL number:
MFCD00011623
UNSPSC Code:
12352200
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Cisplatin, Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

yellow

solubility

PBS with 140 mM NaCl: 1 mg/mL
water with 154 mM NaCl: 1 mg/mL
DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/2Cl.2H3N.Pt/h;;2*1H3;

InChI key

JFUARQHXOQHNLK-UHFFFAOYSA-N

General description

A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
A platinum coordination complex with potent antineoplastic activity.



Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Induces apoptosis in cancer cells
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol.52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Jinan Li et al.
Frontiers in molecular neuroscience, 15, 835448-835448 (2022-03-01)
Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin. In zebrafish, the functional mechanotransduction channel is
Adib Behrouzi et al.
International journal of molecular sciences, 23(3) (2022-02-16)
Cisplatin can induce peripheral neuropathy, which is a common complication of anti-cancer treatment and negatively impacts cancer survivors during and after completion of treatment; therefore, the mechanisms by which cisplatin alters sensory neuronal function to elicit neuropathy are the subject
Shruthi Sriramkumar et al.
Journal of translational medicine, 20(1), 246-246 (2022-06-02)
Platinum based agents-cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistant disease that is uniformly fatal. Platinum treatment enriches for chemoresistant aldehyde
Laura Torresano et al.
Oncogenesis, 11(1), 24-24 (2022-05-10)
Lung cancer is the leading cause of cancer-related death worldwide despite the success of therapies targeting oncogenic drivers and immune-checkpoint inhibitors. Although metabolic enzymes offer additional targets for therapy, the precise metabolic proteome of lung adenocarcinomas is unknown, hampering its
Ali A Shati
Systems biology in reproductive medicine, 65(3), 236-249 (2018-12-07)
This study aimed to investigate the protective role of resveratrol (RES) against cisplatin (Cis)-induced testicular damage and reproductive dysfunction in rats and to examine the underlying mechanisms of protection including its effect on endoplasmic reticulum (ER) stress, P53, extracellular signal-regulated
Ver todos los artículos relacionados

Contenido relacionado

Exploring Genotoxicity Through Multiplexing | MILLIPLEX® Assays

Exploring genotoxicity and DNA damage through multiplexing with MILLIPLEX® multiplex genotoxicity assays using Luminex® xMAP® technology enables the high-throughput measurement of phosphorylation levels of multiple proteins simultaneously and reduces sample volume, time, and cost.

Exploring Genotoxicity Through Multiplexing | MILLIPLEX® Assays

Exploring genotoxicity and DNA damage through multiplexing with MILLIPLEX® multiplex genotoxicity assays using Luminex® xMAP® technology enables the high-throughput measurement of phosphorylation levels of multiple proteins simultaneously and reduces sample volume, time, and cost.

Exploring Genotoxicity Through Multiplexing | MILLIPLEX® Assays

Exploring genotoxicity and DNA damage through multiplexing with MILLIPLEX® multiplex genotoxicity assays using Luminex® xMAP® technology enables the high-throughput measurement of phosphorylation levels of multiple proteins simultaneously and reduces sample volume, time, and cost.

Exploring Genotoxicity Through Multiplexing | MILLIPLEX® Assays

Exploring genotoxicity and DNA damage through multiplexing with MILLIPLEX® multiplex genotoxicity assays using Luminex® xMAP® technology enables the high-throughput measurement of phosphorylation levels of multiple proteins simultaneously and reduces sample volume, time, and cost.

Questions

  1. The SDS seems to contain the wrong information. It does not match the information on the vial and on the website.

    1 answer

    1. The Safety Data Sheet document provided on the product detail page is the correct document. Please access document below: https://www.sigmaaldrich.com/US/en/sds/mm/232120

      For further concerns, we kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquires" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.

      Helpful?

Reviews

No rating value

Active Filters

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico