S7446
Superóxido dismutasa from bovine erythrocytes
BioUltra, lyophilized powder, ≥4,500 units/mg protein, ≥97% (SDS-PAGE)
Sinónimos:
SOD, Superóxido: superóxido oxidorreductasa
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About This Item
Productos recomendados
product line
BioUltra
Quality Level
assay
≥97% (SDS-PAGE)
form
lyophilized powder
specific activity
≥4,500 units/mg protein
mol wt
32.5 kDa
composition
Protein, ≥95% biuret
relevant disease(s)
arthritis
storage temp.
−20°C
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General description
Research area: Cell signaling. Superoxide Dismutase (SOD) is found in allaerobic cells of the animals, plants, and microorganisms. It is a low molecularweight protein that exists as three different forms such as manganese SOD,copper–zinc SOD, and extracellular SOD.
Application
Superoxide Dismutase from bovine erythrocytes has been used in a study to assess activity parameters in adjuvant-induced arthritis. Superoxide Dismutase from bovine erythrocytes has also been used in a study to simplify the process of purifying superoxide dismutases using charge-controlled hydrophobic chromatography on 10-carboxydecyl Sepharose. It has also been used as a standard in SOD assay in mice liver andkidney samples.
Biochem/physiol Actions
La superóxido dismutasa de los eritrocitos bovinos cataliza la dismutación de los radicales superóxido a peróxido de hidrógeno y oxígeno molecular. Actúa como antioxidante y desempeña un papel fundamental en la defensa de las células contra los efectos tóxicos de los radicales de oxígeno. Compite con el óxido nítrico (NO) por el anión superóxido (que reacciona con el NO para formar peroxinitrito), por tanto la SOD promueve la actividad del NO. También se ha demostrado que la SOD suprime la apoptosis en folículos ováricos de rata cultivados, líneas celulares neuronales y ratones transgénicos.
Unit Definition
One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
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Protocolos
Enzymatic Assay of Superoxide Dismutase
Separation of Superoxide dismutase
Chromatograms
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