O4375

Oxytocin

lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

• Sinónimos: α-Hypophamine, Oxytocic hormone
• Fórmula empírica (notación de Hill): C₄₃H₆₆N₁₂O₁₂S₂
• Número de CAS: 50-56-6
• Peso molecular: 1007.19
• Beilstein: 3586108
• Número MDL: MFCD00076731
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 24897994
• NACRES: NA.32
• origen biológico: synthetic
• Formulario: lyophilized powder

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 200
• esterilidad: non-sterile
• Formulario: lyophilized powder
• actividad específica: ~15 IU/mg solid (Prepared from synthetic oxytocin)
• solubilidad: water: 10 mg/mL, clear, colorless
• Nº de acceso UniProt: P01178; P30559; P70536
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
• InChI: 1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
• Clave InChI: XNOPRXBHLZRZKH-DSZYJQQASA-N
• Información sobre el gen: human ... OXT(5020) , OXTR(5021) ; rat ... Oxtr(25342)

Descripción

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

Descripción general

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Aplicación

Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.

Acciones bioquímicas o fisiológicas

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

Stimulates uterine contraction and lactation; increases Na⁺ excretion; stimulates myometrial GTPase and phospholipase C.

Forma física

Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable