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Key Documents

Y0000261

Dextromethorphan impurity A

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

ent-3-Methoxymorphinan

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About This Item

Fórmula empírica (notación de Hill):
C17H23NO
Número de CAS:
1531-23-3
Peso molecular:
257.37
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

dextromethorphan

manufacturer/tradename

EDQM

drug control

estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C17H23NO/c1-19-13-6-5-12-10-16-14-4-2-3-7-17(14,8-9-18-16)15(12)11-13/h5-6,11,14,16,18H,2-4,7-10H2,1H3/t14-,16-,17?/m1/s1

InChI key

ILNSWVUXAPSPEH-IYNBXCLQSA-N

Categorías relacionadas

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dextromethorphan impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Referencia del producto
Descripción
Precios

PHR1018

Dextromethorphan HBr, certified reference material, pharmaceutical secondary standard

1181007

Dextromethorphan hydrobromide, United States Pharmacopeia (USP) Reference Standard

D0740000

Dextromethorphan hydrobromide, European Pharmacopoeia (EP) Reference Standard

1180503

Dextromethorphan, United States Pharmacopeia (USP) Reference Standard

1181040

Dextromethorphan Related Compound C, United States Pharmacopeia (USP) Reference Standard

PHR2206

Dextromethorphan N-Oxide HCl, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1976

Dextromethorphan Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H411

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Yu-Wen Chen et al.
European journal of pharmacology, 569(3), 188-193 (2007-07-03)
Dextromethorphan, an antitussive, has a complex pharmacologic profile and has not been well studied. Our aim was to evaluate whether dextromethorphan and its metabolites, dextrorphan and 3-methoxymorphinan, have a spinal anaesthetic effect. Using a method of spinal blockade in rats
Wen-Hui Tsai et al.
The Chinese journal of physiology, 51(5), 292-300 (2009-01-30)
Dextromethorphan (DM), an antitussive agent, has been shown to have anti-inflammatory and immunomodulatory effects in vitro. Thus, the aim of this study was to evaluate the effects of LK-3, an analog of DM, on sepsis induced by intravenous (i.v.) administration
N L Kerry et al.
Biochemical pharmacology, 45(4), 833-839 (1993-02-24)
The O-demethylation of dextromethorphan (DM) to dextrorphan (DR) is catalysed by the polymorphic CYP2D6 (cytochrome P4502D6) isozyme in man. DM is commonly used as a probe for phenotyping subjects as either poor or extensive metabolizers for the debrisoquine/sparteine oxidative polymorphism
Chia-Hui Hou et al.
European journal of pharmacology, 544(1-3), 10-16 (2006-07-18)
Dextromethorphan has been used as an antitussive for more than 40 years and is considered a drug with a good margin of safety. The aim of the study was to evaluate whether dextromethorphan and its metabolites--3-methoxymorphinan and dextrorphan--had local anaesthetic
L L von Moltke et al.
The Journal of pharmacy and pharmacology, 50(9), 997-1004 (1998-11-12)
Cytochromes mediating the biotransformation of dextromethorphan to dextrorphan and 3-methoxymorphinan, its principal metabolites in man, have been studied by use of liver microsomes and microsomes containing individual cytochromes expressed by cDNA-transfected human lymphoblastoid cells. In-vitro formation of dextrorphan from dextromethorphan
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