938785

Sodium tert-butoxide ChemBeads

• Sinónimos: NaOtBu, Sodium 2-methylpropan-2-olate, Sodium t-butoxide, Sodium tert-butanolate, Sodium tert-butylate
• Número de CAS: 865-48-5
• MDL number: MFCD00040575
• UNSPSC Code: 12352100

Propiedades

• form: solid ()
• Quality Level: 100
• composition: loading of base, 14-16 wt. %
• SMILES string: [Na+].CC(C)(C)[O-]
• InChI: 1S/C4H9O.Na/c1-4(2,3)5;/h1-3H3;/q-1;+1
• InChI key: MFRIHAYPQRLWNB-UHFFFAOYSA-N

Descripción

Application

Sodium tert-butoxide may be used as a safe and effective alternative to sodium hydride for the coupling of hydroxyethyl adenine with diethyl p-toluenesulfonyloxymethanephosphonate to form 9-[2-(diethylphosphonomethoxy)ethyl]adenine (diethyl-PMEA), which is a key intermediate to prepare adefovir dipivoxil.
It can also be used:
- To facilitate the coupling of aryl halides with benzene derivatives in the presence of 10-phenanthroline derivative.
- To activate first-row transition-metal pre-catalysts.
- As a base for the amination of aryl chlorides in the presence of a novel palladacyclic precatalyst.
For general uses, product is also available in powdered form (359270)

Features and Benefits

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

Información de seguridad

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H228,H251,H314
• pcodes: P210 - P235 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Sol. 1 - Self-heat. 1 - Skin Corr. 1B
• supp_hazards: EUH014
• Storage Class: 4.2 - Pyrophoric and self-heating hazardous materials
• wgk_germany: WGK 3