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Sigma-Aldrich

PAMAM dendrimer

ethylenediamine core, generation 0.0 solution, 20 wt. % in methanol

Sinónimos:

Poly(amidoamine)

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About This Item

Fórmula lineal:
NH2(CH2)2NH2]:(G=0);dendri PAMAM(NH2)4
Número de CAS:
155773-72-1
Peso molecular:
516.68
Número MDL:
MFCD00192446
Código UNSPSC:
12162002
ID de la sustancia en PubChem:
24865805
NACRES:
NA.23
En este momento no podemos mostrarle ni los precios ni la disponibilidad

descripción

amino surface groups

Nivel de calidad

200

Formulario

liquid

mol peso

generation 0.0

Características

core type ethylenediamine core (2-carbon core)

concentración

20 wt. % in methanol

nº de grupos superficiales

4

índice de refracción

n20/D 1.364

bp

64.7 °C

densidad

0.854 g/mL at 25 °C

temp. de almacenamiento

2-8°C

cadena SMILES

NCCNC(=O)CCN(CCN(CCC(=O)NCCN)CCC(=O)NCCN)CCC(=O)NCCN

InChI

1S/C22H48N10O4/c23-5-9-27-19(33)1-13-31(14-2-20(34)28-10-6-24)17-18-32(15-3-21(35)29-11-7-25)16-4-22(36)30-12-8-26/h1-18,23-26H2,(H,27,33)(H,28,34)(H,29,35)(H,30,36)

Clave InChI

SENLDUJVTGGYIH-UHFFFAOYSA-N

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Descripción general

PAMAM dendrimer is a poly(amidoamine) that is categorized under the class of dendritic polymers, which can be prepared by a two-step reaction that forms generations around the central ethylenediamine core. It consists of nitrogen and amide as functional groups that are structured in regular branched upon branched pattern. PAMAM is majorly used as a high capacity chelating agent.[1][2]

Aplicación

PAMAM dendrimer belongs to the family of dendrimers, which can be used in biomedical and drug delivery applications.[3][4][5]

Forma física

Contains 4 surface primary amino groups

Información legal

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes,Central nervous system

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

49.5 °F - closed cup

Punto de inflamabilidad (°C)

9.7 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number
MKCW5450
MKCT9515
MKCS4387
MKCR3539
MKCQ6407

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PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality
Majoros I, et al.
Biomacromolecules, 7(2), 572-579 (2006)
Poly (amidoamine)(PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications
Esfand R and Tomalia DA
Drug Discovery Today, 6(8), 427-436 (2001)
Poly (ethylene glycol)-conjugated PAMAM dendrimer for biocompatible, high-efficiency DNA delivery
Luo D, et al.
Macromolecules, 35(9), 3456-3462 (2002)
Dendritic chelating agents. 1. Cu (II) binding to ethylene diamine core poly (amidoamine) dendrimers in aqueous solutions
Diallo MS, et al.
Langmuir, 20(7), 2640-2651 (2004)
Dendrimer enhanced ultrafiltration. 1. Recovery of Cu (II) from aqueous solutions using PAMAM dendrimers with ethylene diamine core and terminal NH2 groups
Diallo MS, et al.
Environmental Science & Technology, 39(5), 1366-1377 (2005)
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Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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