165336

Methylboronic acid

97%

• Sinónimos: Methaneboronic acid
• Fórmula lineal: CH₃B(OH)₂
• Número de CAS: 13061-96-6
• Peso molecular: 59.86
• Beilstein/REAXYS Number: 1731087
• MDL number: MFCD00002105
• UNSPSC Code: 12352103
• PubChem Substance ID: 24850133
• NACRES: NA.22

Propiedades

• Quality Level: 100
• assay: 97%
• form: solid
• mp: 91-94 °C (lit.)
• SMILES string: CB(O)O
• InChI: 1S/CH5BO2/c1-2(3)4/h3-4H,1H3
• InChI key: KTMKRRPZPWUYKK-UHFFFAOYSA-N

Descripción

Application

Methylboronic acid can be used as a reagent:

• In the palladium-catalyzed Stille and Suzuki-Miyaura cross-couplings.
• In the microwave-heated heterogeneous palladium (Pd)-catalytized reactions.
• In ruthenium (Ru)-catalyzed silylation reactions
• To prepare bis(aminotropone) titanium (Ti) catalysts for ethylene polymerizations.
• In the enantioselective asymmetric bromoaminocyclization and bromoaminocyclization using amino-thiocarbamate catalysts.
• To prepare common building blocks for pharmaceuticals and agrochemicals.
• To prepare chrysin analogs by Suzuki-Miyaura coupling reactions.
• To prepare casein kinase I inhibitors.
• In the divergent C-H functionalizations directed by sulfonamide pharmacophores in drug discovery.
• In the synthesis of unsymmetrical monosulfides from disulfides via copper-catalyzed coupling with boronic acids.
• In a palladium-catalyzed coupling with enol tosylates.
• For derivatizing many carbohydrates and biologically active compounds for GLC analysis.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves