Y102

YC-1

powder

• Sinónimos: 3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl indazole
• Fórmula empírica (notación de Hill): C₁₉H₁₆N₂O₂
• Número de CAS: 170632-47-0
• Peso molecular: 304.34
• Número MDL: MFCD06407798
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 24278782
• NACRES: NA.77

Propiedades

• Formulario: powder
• Nivel de calidad: 200
• color: white to yellow
• solubilidad: DMSO: 10 mg/mL; H₂O: insoluble
• cadena SMILES: OCc1ccc(o1)-c2nn(Cc3ccccc3)c4ccccc24
• InChI: 1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
• Clave InChI: OQQVFCKUDYMWGV-UHFFFAOYSA-N
• Información sobre el gen: human ... PDE5A(8654)

Descripción

Aplicación

YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:

• to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs)
• to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming units
• to study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.

Acciones bioquímicas o fisiológicas

NO (nitric oxide)-independent activator of soluble guanylyl cyclase.

YC-1 activates soluble guanylyl cyclase and prevents platelet aggregation and vascular contraction. It has a potential to treat circulation disorders. YC-1 also has an ability to inhibit hypoxia-inducible factor 1α (HIF-1α) activity in vitro. It acts as a potential antiangiogenic anticancer agent.

Características y beneficios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)