Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
S4572
SANT-1
≥98% (HPLC), powder, SHH antagonist
Sinónimos:
(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
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About This Item
Fórmula empírica (notación de Hill):
C23H27N5
Número de CAS:
Peso molecular:
373.49
Número MDL:
Código UNSPSC:
51111800
ID de la sustancia en PubChem:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad
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Nombre del producto
SANT-1, ≥98% (HPLC), powder
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
powder
solubilidad
DMSO: 5 mg/mL, clear (warmed)
temp. de almacenamiento
−20°C
cadena SMILES
Cc1nn(-c2ccccc2)c(C)c1\C=N\N3CCN(CC3)Cc4ccccc4
InChI
1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
Clave InChI
FOORCIAZMIWALX-JJIBRWJFSA-N
Aplicación
- SANT-1 has been used: to treat cells and study the effect of SANT1-mediated inhibition on hedgehog signaling[1]
- in the generation of functional human pancreatic β cells in vitro[2]
- to treat of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death
Acciones bioquímicas o fisiológicas
SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.
SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist.
SANT-1 is known to induce apoptosis via Ras/NF-κB pathway in glioblastoma cells.[3]
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Los clientes también vieron
Deobrat Dixit et al.
Cancer letters, 336(2), 347-358 (2013-04-04)
Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade
Felicia W Pagliuca et al.
Cell, 159(2), 428-439 (2014-10-11)
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide an unprecedented cell source for drug discovery and cell transplantation therapy in diabetes. However, insulin-producing cells previously generated from human pluripotent stem cells (hPSC) lack many
P Desch et al.
Oncogene, 29(35), 4885-4895 (2010-07-07)
The Hedgehog (Hh) pathway regulates cell proliferation and survival and contributes to tumorigenesis. We investigated the expression and function of this pathway in B-cell chronic lymphocytic leukemia (CLL) cells and in healthy B lymphocytes. Profiling of cognate Hh pathway members
Bushra Memon et al.
Stem cell research & therapy, 9(1), 15-15 (2018-01-25)
Pancreatic progenitors (PPs) co-expressing the two transcription factors (TFs) PDX1 and NKX6.1 are recognized as the indispensable precursors of functional pancreatic β cells. Here, we aimed to establish an efficient protocol for maximizing generation of PDX1 In order to enhance
Shuhei Konagaya et al.
Scientific reports, 9(1), 640-640 (2019-01-27)
Large numbers of hormone-releasing cells, approximately 109 endocrine cells, are required to treat type I diabetes patients by cell transplantation. The SOX9-positive pancreatic epithelium proliferates extensively during the early stages of pancreatic development. SOX9-positive pancreatic epithelium is thought to be
Artículos
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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