SML1868

Brusatol

≥95% (HPLC)

• Sinónimos: (+)-Brusatol, (11β,12α,15β)-13,20-Epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-picras-3-en-21-oic acid methyl ester, Brutasol, NSC 172924, Yatansin
• Fórmula empírica (notación de Hill): C₂₆H₃₂O₁₁
• Número de CAS: 14907-98-3
• Peso molecular: 520.53
• Número MDL: MFCD23726642
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• origen biológico: (Brucia javanica)
• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: powder
• actividad óptica: [α]/D +35 to +44°, c = 0.5 in acetone
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: DMSO: 5 mg/mL, clear (warmed)
• temp. de almacenamiento: −20°C
• cadena SMILES: CC1=C(O)C(C[C@@]2(C)[C@@]1([H])C[C@]3([H])[C@]45[C@]2([H])[C@@H](O)[C@H](O)[C@](OC5)(C(OC)=O)[C@]4([H])[C@@H](OC(C=C(C)C)=O)C(O3)=O)=O
• InChI: 1S/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2,1-5H3/t12-,14+,17+,18+,19+,20+,21-,24-,25+,26-/m0/s1
• Clave InChI: ZZZYHIMVKOHVIH-VILODJCFSA-N

Descripción

Aplicación

Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.[1]

Acciones bioquímicas o fisiológicas

Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC₅₀ <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. <50 nM in A549 cells), including NRF2.

Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity.

Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation.[2] Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.[3]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable