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SCP0148

Sigma-Aldrich

Furin Inhibitor II Peptide

≥95% (HPLC), lyophilized powder

Sinónimos:

Hexa-D-arginine amide

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About This Item

Fórmula empírica (notación de Hill):
C36H75N25O6
Peso molecular:
954.14
Código UNSPSC:
12352202
NACRES:
NA.32

Nombre del producto

Furin Inhibitor II,

Ensayo

≥95% (HPLC)

Formulario

lyophilized

composición

Peptide Content, ≥48%

condiciones de almacenamiento

protect from light

técnicas

protein extraction: suitable

temp. de almacenamiento

−20°C

Amino Acid Sequence

Mpa-Mpa-Mpa-Mpa-Mpa-Mpa

Descripción general

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.

Aplicación

Furin Inhibitor II has been used as a furin inhibitor:
  • to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
  • to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
  • in furin cleavage assay.

Acciones bioquímicas o fisiológicas

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Polyarginines are potent furin inhibitors
Cameron A, et al.
The Journal of Biological Chemistry, 275(47), 36741-36749 (2000)
Emily J Schepers et al.
The Journal of surgical research, 282, 118-128 (2022-10-23)
Glypican-3 (GPC3) is a surface-bound proteoglycan overexpressed in pediatric liver cancer and utilized clinically as an immunohistochemical tumor marker. Furin is a proprotein convertase that is ubiquitously expressed and shown to modify GPC3 post-translationally. In experimental models of epithelial-based cancers
Jingwen Yin et al.
Cells, 9(1) (2020-01-16)
Glial cell line-derived neurotrophic factor (GDNF) is expressed at a high level in the human ovary and GDNF signaling is involved in the direct control of follicular activation and oocyte maturation. Transforming growth factor-β1 (TGF-β1) plays an important role in
A Cameron et al.
The Journal of biological chemistry, 275(47), 36741-36749 (2000-08-26)
The ubiquitous serine endoprotease furin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in the metastatic progression of certain tumors. Although high molecular mass bioengineered serpin inhibitors have been well characterized, no small
Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme
Dubois C M, et al.
The American Journal of Pathology, 158(1), 305-316 (2001)

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