S1318

STO-609-acetic acid

≥95% (HPLC), solid

• Sinónimos: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid - acetic acid
• Fórmula empírica (notación de Hill): C₁₉H₁₀N₂O₃ · C₂H₄O₂
• Número de CAS: 1173022-21-3
• Peso molecular: 374.35
• Número MDL: MFCD06411456
• Código UNSPSC: 12352106
• ID de la sustancia en PubChem: 329824472
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• mp: >300 °C
• solubilidad: DMSO: 5 mg/mL, clear (warmed)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CC(O)=O.OC(=O)c1ccc2-c3nc4ccccc4n3C(=O)c5cccc1c25
• InChI: 1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)
• Clave InChI: WNRSTFUVBWNELX-UHFFFAOYSA-N

Descripción

Descripción general

1:1 adduct with acetic acid

STO-609 reduces tumorigenicity of liver cancer cells in vivo.[1] TO-609 reduces the activation of AMP (adenosine monophosphate)-activated protein kinase (AMPK) by ionomycin in a dose dependant manner.[2]

Aplicación

STO609 has been used as a calcium/calmodulin-dependent protein kinase kinase (CAMKK) inhibitor in mouse MLL-AF9 acute myeloid leukemia (AML) cells.[3]

Acciones bioquímicas o fisiológicas

Selective Ca²⁺/Calmodulin-dependent protein kinase kinase (CaM-KK) antagonist.

Selective Ca²⁺/Calmodulin-dependent protein kinase kinase (CaM-KK) antagonist. Inhibits CamKKa and CaMKKb with K_i = 80 and 15 ng/mL, respectively. Does not inhibit downstream CaM kinases (CaMKI and CaMKIV).

Características y beneficios

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)