H2414
Anti-Humanin (HN) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Humanin Detection Antibody, Rabbit Anti-Humanin
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
human
técnicas
western blot: 1:500
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... MT-RNR2(4550)
Descripción general
Humanin (HN) is a small polypeptide, derived from mitochondria. This protein is secreted by various cells and is localized in the plasma and bound to the cell membranes.
Inmunógeno
peptide corresponding to the humanin protein (amino acids 9-24).
Aplicación
Anti-Humanin (HN) antibody produced in rabbit has been used in:
- immunohistochemistry
- immunoprecipitation (1:300)
- fluorescent immunohistochemistry (1:300)
- immunoblotting (1:500)
Acciones bioquímicas o fisiológicas
Humanin (HN) acts as a neuroprotective factor. It is involved in promoting cell survival. Humanin suppresses cell death in the neuronal cells caused by Alzheimer′s disease-related insults like anti-amyloid- precursor protein antibody, neurotoxic amyloid β (Aβ) peptides, and familial Alzheimer disease proteins.
Forma física
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Yue Jia et al.
Biology of reproduction, 104(3), 717-730 (2020-12-18)
Humanin (HN) is a mitochondrial-derived peptide that protects many cells/tissues from damage. We previously demonstrated that HN reduces stress-induced male germ cell apoptosis in rodents. HN action in neuronal cells is mediated through its binding to a trimeric cell membrane
Mariela A Moreno Ayala et al.
Scientific reports, 10(1), 8542-8542 (2020-05-24)
Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from chemotherapy, its role in tumor
Radhika H Muzumdar et al.
PloS one, 4(7), e6334-e6334 (2009-07-23)
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against
Jon-Philippe K Hyatt et al.
Journal of dietary supplements, 20(4), 563-581 (2022-03-02)
Mitochondrial biogenesis and destruction in skeletal muscle are coordinated by distinct signaling pathways that are influenced by internal and exogenous variables including, but not limited to, muscle phenotype, physical activity, dietary composition, or drug administration. Previously we found that long-term
Xingshun Xu et al.
Stroke, 37(10), 2613-2619 (2006-09-09)
Humanin (HN) is a 24-amino acid peptide best known for its ability to protect neurons from damage caused by Alzheimer disease-related proteins. This study examines the neuroprotective effects of HNG (a potent form of HN) on focal cerebral ischemia/reperfusion injury
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
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