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GW22489

Sigma-Aldrich

Anti-GNAI3 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-87U6, Anti-ARCND1, Anti-HG1A

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

manufacturer/tradename

Genway 15-288-22489

technique(s)

immunocytochemistry: suitable
western blot: suitable

NCBI accession no.

NP_006487.1

UniProt accession no.

P08754

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GNAI3(2773)

Immunogen

Immunogen Sequence: GI # 5729850, sequence 345-353
Synthetic peptide sequence of guanine nucleotide binding protein (G protein), α inhibiting activity polypeptide 3.

Application

Anti-GNAI3 antibody produced in chicken is suitable for immunocytochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Guanine nucleotide-binding protein G(k) subunit α is a protein encoded by the GNAI3 gene in humans. It is composed of α, β and γ subunits and mediates hormonal regulation of many membrane functions. GNAI3 subunit translocations to the cytoskeleton and its simultaneous inhibition indicates that the cytoskeleton might participate in the signaling process of human epithelial cells.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Anil Akturk et al.
Science advances, 8(42), eabq2826-eabq2826 (2022-10-20)
Inhibitory G proteins (GNAI/Gαi) bind to the scaffold G protein signaling modulator 2 (GPSM2) to form a conserved polarity complex that regulates cytoskeleton organization. GPSM2 keeps GNAI in a guanosine diphosphate (GDP)-bound state, but how GPSM2-GNAI is generated or relates
S Y Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(12), 4153-4157 (1988-06-01)
The guanine nucleotide-binding proteins (G proteins), which mediate hormonal regulation of many membrane functions, are composed of alpha, beta, and gamma subunits. We have cloned and characterized cDNA from a human T-cell library encoding a form of alpha i that
J L Adolfsson et al.
Biochemical and biophysical research communications, 226(2), 413-419 (1996-09-13)
The present results show that stimulation of Intestine 407 epithelial cells with LTD4 (Leukotriene D4) triggers a rapid activation of the pertussis-toxin-sensitive Gi3-protein and a simultaneous translocation of its alpha-subunits to a crude cytoskeletal fraction. The activation of G alpha
Katie S Kindt et al.
Nature communications, 12(1), 2861-2861 (2021-05-19)
Hair cells detect sound, head position or water movements when their mechanosensory hair bundle is deflected. Each hair bundle has an asymmetric architecture that restricts stimulus detection to a single axis. Coordinated hair cell orientations within sensory epithelia further tune

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