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D8399

Sigma-Aldrich

Danazol

≥98% (TLC), powder, androgen receptor agonist

Sinónimos:

17β-Hydroxy-2,4,17α-pregnadien-20-yno[2,3-d]isoxazole, 2,4,17α-Pregnadien-20-yno[2,3-d]­isoxa­zol-17-ol

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About This Item

Fórmula empírica (notación de Hill):
C22H27NO2
Número de CAS:
17230-88-5
Peso molecular:
337.46
EC Number:
241-270-1
MDL number:
MFCD00056838
UNSPSC Code:
51111800
PubChem Substance ID:
24277708
NACRES:
NA.77

product name

Danazol, ≥98%

assay

≥98%

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

originator

Sanofi Aventis

SMILES string

CC12Cc3cnoc3C=C1CCC4C2CCC5(C)C4CC[C@@]5(O)C#C

InChI

1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16?,17?,18?,20?,21?,22-/m0/s1

InChI key

POZRVZJJTULAOH-ZIKCMSSPSA-N

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Biochem/physiol Actions

Danazol is a weak androgen; anterior pituitary suppressant.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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E Hughes et al.
The Cochrane database of systematic reviews, (1)(1), CD000069-CD000069 (2007-01-27)
The synthetic androgen Danazol, was developed in the 1970's as a treatment for endometriosis. Its use was soon advocated in women with unexplained subfertility. Two randomised trials were subsequently conducted to assess the effectiveness of danazol in this population. The
Hywel D Williams et al.
Journal of pharmaceutical sciences, 101(9), 3360-3380 (2012-05-31)
The Lipid Formulation Classification System Consortium is an industry-academia collaboration, established to develop standardized in vitro methods for the assessment of lipid-based formulations (LBFs). In this first publication, baseline conditions for the conduct of digestion tests are suggested and a
Johannes Parmentier et al.
International journal of pharmaceutics, 437(1-2), 253-263 (2012-09-04)
Liposomes are generally well tolerated drug delivery systems with a potential use for the oral route. However, little is known about the fate of liposomes during exposure to the conditions in the gastro-intestinal tract (GIT). To gain a better understanding
Terry Gernsheimer et al.
Blood, 121(1), 38-47 (2012-11-15)
A mild thrombocytopenia is relatively frequent during pregnancy and has generally no consequences for either the mother or the fetus. Although representing no threat in the majority of patients, thrombocytopenia may result from a range of pathologic conditions requiring closer
Gregory W Thomas et al.
Biochemical and biophysical research communications, 421(4), 707-712 (2012-05-01)
Breakdown of endothelial barrier function is a hallmark event across a variety of pathologies such as inflammation, cancer, and diabetes. It has also been appreciated that steroid hormones impart direct biological activity on endothelial cells at many levels. The purpose
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