T1500

Testosterone

≥98%

• Sinónimos: 17β-Hydroxy-3-oxo-4-androstene, 17β-Hydroxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one, trans-Testosterone
• Fórmula empírica (notación de Hill): C₁₉H₂₈O₂
• Número de CAS: 58-22-0
• Peso molecular: 288.42
• Beilstein: 1915399
• Número CE: 200-370-5
• Número MDL: MFCD00003654
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 24899970
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• esterilidad: non-sterile
• Ensayo: ≥98%
• Formulario: powder
• control farmacológico: USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
• solubilidad: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 18.2 mg/ml; absolute ethanol: soluble 0.5 mg/ml; chloroform: soluble 100 mg/mL, clear, colorless to very faintly yellow; H₂O: insoluble; dioxane: soluble; methanol: soluble; methyl oleate: slightly soluble; vegetable oils: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: room temp
• cadena SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
• InChI: 1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
• Clave InChI: MUMGGOZAMZWBJJ-DYKIIFRCSA-N
• Información sobre el gen: human ... AR(367) , EBP(10682) , ESR1(2099) , PGR(5241) , SERPINA6(866) , SHBG(6462) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Esr1(24890) , Nr3c1(24413) , Nr3c2(25672) , Pgr(25154)

Descripción

Aplicación

Testosterone has been used as a standard to study the developmental profile of steroid hormones in male and female rat brains. This hormone has also been used to evaluate its effects on muscle mass and signaling in mice.

Acciones bioquímicas o fisiológicas

Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

Testosterone dissolves in chloroform at 100 mg/ml to yield a clear, colorless to very faint yellow solution. It is also soluble in methanol, absolute ethanol (0.5 mg/ml), 45 percent (w/v) aqueous 2-hydroxypropyl-b-cyclodextrin (18.2 mg/ml), vegetable oils and dioxane. It is slightly soluble in methyl oleate and insoluble in water.

Información de seguridad

• Pictogramas: GHS08,GHS07,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H302,H351,H360FD,H400
• Consejos de prudencia: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges