D4628

Diethylstilbestrol

≥99% (HPLC)

• Sinónimos: (E)-3,4-Bis(4-hydroxyphenyl)-3-hexene, DES, Stilbestrol
• Fórmula empírica (notación de Hill): C₁₈H₂₀O₂
• Número de CAS: 56-53-1
• Peso molecular: 268.35
• Beilstein/REAXYS Number: 2056095
• EC Number: 200-278-5
• MDL number: MFCD00002373
• UNSPSC Code: 51111800
• PubChem Substance ID: 24893887
• NACRES: NA.77

Propiedades

• Quality Level: 200
• assay: ≥99% (HPLC)
• form: powder
• SMILES string: CC\C(c1ccc(O)cc1)=C(\CC)c2ccc(O)cc2
• InChI: 1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+
• InChI key: RGLYKWWBQGJZGM-ISLYRVAYSA-N
• Gene Information: human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Esr1(24890)

Descripción

Application

Diethylstilbestrol has been used:

• to evaluate the estrogenic activity of diethylstilbestrol by quantitating the expression levels of endogenous estrogen-regulated marker genes[1]
• to evaluate the estrogenic, androgenic and toxicity responses in bioluminescent yeast bioreporter assay (BLYES)[2]
• to detect its effect on the proliferation and tyrosinase activity of melanocytes[3]

Biochem/physiol Actions

Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.

Información de seguridad

• pictograms: GHS08,GHS07,GHS09
• signalword: Danger
• hcodes: H315,H319,H335,H350,H360FD,H410
• pcodes: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges