Drug metabolism and disposition: the biological fate of chemicals, 47(10), 1093-1096 (2019-07-22)
Although the pathophysiology of carbamazepine-induced idiosyncratic or hypersensitivity reactions is unclear, they are presumed to be immune mediated, involving a complex interaction between drug metabolism and activation of the immune system. Cell stress can be caused by reactive metabolites, and
The Journal of biological chemistry, 258(22), 13575-13579 (1983-11-25)
A novel compound, 3-(2'-aminobenzhydryloxy)-tropane (ABT), and an ABT-agarose gel were synthesized and used for the purification of solubilized muscarinic receptors. ABT had a high affinity with an apparent dissociation constant (Kd) of 7 nM for the muscarinic receptors solubilized from
The Journal of toxicological sciences, 42(5), 641-650 (2017-09-15)
The utility of HepaRG cells as an in vitro cell-based assay system for predicting drug-induced phospholipidosis (PLD) was investigated. In experiment 1, 10 PLD-positive compounds and 11 PLD-negative compounds were selected. HepaRG cells were treated with each compound for 48
Pulsed antibiotic treatment (PAT) early in life increases risk of obesity. Prebiotics can reduce fat mass and improve metabolic health. We examined if co-administering prebiotic with PAT reduces obesity risk in rat pups weaned onto a high fat/sucrose diet. Pups
The Science of the total environment, 688, 398-408 (2019-06-28)
Elevated levels of airborne particulate matter (PM) pose health risks to populations living in many cities worldwide. To remediate the impact of air pollution, urban greening has been increasingly explored as a possible way to remove PM from the surroundings.
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