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D6750

Sigma-Aldrich

Sodium deoxycholate

≥97% (titration)

Sinónimos:

3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt

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About This Item

Fórmula empírica (notación de Hill):
C24H39NaO4
Número de CAS:
302-95-4
Peso molecular:
414.55
Beilstein/REAXYS Number:
3581950
EC Number:
206-132-7
MDL number:
MFCD00064139
UNSPSC Code:
12161900
PubChem Substance ID:
24894044
NACRES:
NA.21
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description

anionic

Quality Level

200

assay

≥97% (titration)

form

powder

mol wt

micellar avg mol wt 1200-5000

aggregation number

3-12

CMC

2-6 mM (20-25°C)

solubility

water: 50 mg/mL, clear, colorless to light yellow

HLB

16

functional group

carboxylic acid

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

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General description

Deoxycholic acid sodium salt, also known as Sodium Deoxycholate, is a highly versatile ionic detergent utilized for its exceptional ability to solubilize membrane-bound proteins and lyse cells. Its mechanism involves disrupting cell membranes and dissolving hydrophobic molecules, making it an invaluable reagent in scientific research applications. In protein research, it plays a pivotal role in solubilizing proteins, particularly those embedded in membranes, enabling their extraction, purification, and subsequent analysis.

Moreover, Sodium Deoxycholate extends its utility to nucleic acid extraction from cells and tissues. By lysing cells and disrupting cellular structures, it facilitates the release and purification of nucleic acids, proving valuable in cell biology and biochemical research. Beyond these applications, its effectiveness in cell lysis processes positions it as a valuable tool for breaking down cells and releasing their contents, finding applications in diverse biological studies, encompassing microscopy, cell biology, and biochemical research.

Application

Sodium deoxycholate has been used in the lysis buffer prepared for brown adipose tissue.[1] It has been used in the decellularization of aortic valvular conduit.[2]

Biochem/physiol Actions

Solubilizes fats for absorption in the intestines.

Features and Benefits

Highly versatile surfactant for your cell biology and biochemical research

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000414262
0000414262
0000410070
0000410068
0000408504

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Chemistry and biology of bile acids.
Mukhopadhyay S and Maitra U
Current Science, 87, 1666-1683 (2004)
Methods in Cell Biology (1974)
Development of decellularized aortic valvular conduit coated by heparin-SDF-1a multilayer.
Zhou J et al.
The Annals of Thoracic Surgery, 99, 612-612 (2015)
Jingxin Zhou et al.
The Annals of thoracic surgery, 99(2), 612-618 (2014-12-17)
Decellularization can reduce the immune response to aortic valve allograft tissue, but the thrombogenicity and in vivo remolding of these grafts remain controversial. The aim of the present study was to modify the surface of decellularized valvular conduits with heparin-stromal
L L Liu et al.
Oncogene, 33(24), 3140-3150 (2013-07-16)
Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple mechanisms, one of which is to express constitutively active androgen receptor (AR) splice variants lacking the ligand-binding domain. AR splice variant 7 (AR-V7, also termed AR3) is the most
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Protocolos

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Surfactant-assisted dispersion of single-walled carbon nanotubes for debundling or exfoliation in dispersion procedures.

Single-walled Carbon Nanotubes: Exfoliation and Debundling Procedure

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Questions

1–3 of 3 Questions  

  1. How safe is this product when used on animals?

    1 answer

    1. This product is intended for research use only and is not suitable for human or veterinary use. While not tested for in vitro or in vivo use, this product has been used successfully in animal models by other customers. Please see the links below to review example publications:

      Corroboration of naringin effects on the intestinal absorption and pharmacokinetic behavior of candesartan cilexetil solid dispersions using in-situ rat models.
      https://pubmed.ncbi.nlm.nih.gov/24918161/

      MicroRNA-101 inhibits rat cardiac hypertrophy by targeting Rab1a.
      https://pubmed.ncbi.nlm.nih.gov/25850725/

      A model of metabolic syndrome and related diseases with intestinal endotoxemia in rats fed a high fat and high sucrose diet.
      https://pubmed.ncbi.nlm.nih.gov/25502558/

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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