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Key Documents

235752

Sigma-Aldrich

Anti-C-Reactive Protein Rabbit pAb

liquid, Calbiochem®

Sinónimos:

Anti-CRP

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgG

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CRP(1401)

General description

Rabbit polyclonal antibody purified by DEAE anion exchange chromatography. Recognizes C-reactive protein.
Recognizes C-reactive protein. Does not exhibit cross-reactivity against normal human serum.

Immunogen

purified, human CRP

Application

ELISA (see application references)

Immunoblotting (0.1 µg/ml,see application references)

Immunoprecipitation (see comments)

Radioimmunoassay (see comments)

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 15 mM phosphate buffer, pH 7.2-7.4.

Other Notes

Exhibits a single precipitin line against CRP control serum. Does not exhibit cross-reactivity against normal human serum. The optimal dilution for RIA and immunoprecipitation should be determined for each sample type. Antibody should be titrated for optimal results in individual systems.
Ridker, P.M., et al. 1997. N. Engl. J. Med.336, 973.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Maurice Swinkels et al.
Scientific reports, 8(1), 1643-1643 (2018-01-28)
Retinal inflammation plays a key role in the progression of age-related macular degeneration (AMD), a condition that leads to loss of central vision. The deposition of the acute phase pentraxin C-reactive protein (CRP) in the macula activates the complement system
Donald N Ngwa et al.
Frontiers in immunology, 11, 586669-586669 (2020-10-30)
C-reactive protein (CRP) binds to several species of bacterial pathogens including Streptococcus pneumoniae. Experiments in mice have revealed that one of the functions of CRP is to protect against pneumococcal infection by binding to pneumococci and activating the complement system.
Anika Alberts et al.
Frontiers in immunology, 11, 596103-596103 (2020-12-29)
Endogenous and exogenous crystalline structures are involved in various pathologies and diseases in humans by inducing sterile inflammation, mechanical stress, or obstruction of excretory organs. The best studied of these diseases is gout, in which crystallization of uric acid in
Asmita Pathak et al.
Frontiers in immunology, 11, 1780-1780 (2020-08-28)
The aim of this study was to test the hypothesis that C-reactive protein (CRP) protects against the development of atherosclerosis and that a conformational alteration of wild-type CRP is necessary for CRP to do so. Atherosclerosis is an inflammatory cardiovascular
Anika Alberts et al.
Scientific reports, 10(1), 6391-6391 (2020-04-15)
Gout is caused by crystallization of uric acid in the form of monosodium urate (MSU) crystals, which induce a sterile inflammatory response that is hardly distinguishable from microbe-induced inflammatory responses. It is unclear, if MSU crystals (like microbes) are recognized
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