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T-911

Supelco

α-Hydroxytriazolam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C17H12Cl2N4O
Número de CAS:
37115-45-0
Peso molecular:
359.21
Número CE:
200-659-6
Código UNSPSC:
41116107
NACRES:
NA.24

grado

certified reference material

Nivel de calidad

300

Formulario

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

concentración

1.0 mg/mL in methanol

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

clinical testing

Formato

single component solution

temp. de almacenamiento

2-8°C

cadena SMILES

OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12

InChI

1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2

Clave InChI

BHUYWUDMVCLHND-UHFFFAOYSA-N

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Descripción general

a-Hydroxytriazolam is a major urinary and blood metabolite of the benzodiazepine, triazolam, a pharmaceutical used to treat severe insomnia. This certified solution standard is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Referencia del producto
Descripción
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B-905

Benzodiazepine Internal Standard-3 solution, 0.5-1.0 mg/mL in acetonitrile, ampule of 1.0 mL, certified reference material, Cerilliant®

T-908

Triazolam-d4 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

T-909

α-Hydroxytriazolam-d4 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

T-910

Triazolam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

T-916

α-Hydroxytriazolam-d4 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

F-047

Flubromazolam solution, 1.0 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

T-167

Temazepam-D5 glucuronide lithium salt solution, 100 μg/mL in methanol ((as free carboxylate)), certified reference material, ampule of 1 mL, Cerilliant®

L-059

Lorazepam-D4 glucuronide lithium salt solution, 100 μg/mL (Acetonitrile:Water (50:50) (v/v), (as free acid)), certified reference material, ampule of 1 mL, Cerilliant®

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes,Central nervous system

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

49.5 °F - closed cup

Punto de inflamabilidad (°C)

9.7 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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A D Fraser et al.
Journal of analytical toxicology, 16(6), 347-350 (1992-11-01)
Triazolam is a very short-acting triazolobenzodiazepine with sedative-hypnotic properties. Approximately 2% of an oral dose is excreted unchanged in the urine. The major urinary metabolite is alpha-hydroxytriazolam glucuronide (70% of the dose). The objective of this study was to characterize
Dora Farkas et al.
Journal of clinical pharmacology, 47(3), 286-294 (2007-02-27)
The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam alpha-hydroxylation)
Fumio Moriya et al.
Legal medicine (Tokyo, Japan), 5 Suppl 1, S91-S95 (2003-08-26)
A 57-year-old man was found dead lying down in a bamboo thicket. Moderate to severe petechiae were present on his conjunctivae, buccal mucosa, and laryngeal mucosa at autopsy. Cardiac chambers contained a normal volume of fluid blood. Moderate atherosclerosis and
Qiran Sun et al.
Journal of analytical toxicology, 34(2), 89-94 (2010-03-13)
A sensitive liquid chromatography-tandem mass spectrometry method is presented for determination of triazolam and alpha-hydroxytriazolam in guinea pig hair after a single dose of triazolam. Eighteen guinea pigs were divided into three dosage groups (10, 100, and 500 microg/kg) and
Kenji Tsujikawa et al.
Journal of analytical toxicology, 29(4), 240-243 (2005-06-25)
The objective of this study was to examine urinary excretion profiles of two major triazolam metabolites, alpha-hydroxytriazolam (alpha-OHTRZ) and 4-hydroxytriazolam (4-OHTRZ) in humans. Urine samples were collected from three healthy male volunteers who had been previously administered single 0.25- and
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