653152

4-Mercaptophenylacetic acid

97%

• Sinónimos: (4-Carboxymethyl)thiophenol, (4-Sulfanylphenyl)acetic acid, 2-(4-Mercaptophenyl)acetic acid, 2-(4-Sulfanylphenyl)acetic acid, 4-Mercaptobenzeneacetic acid, p-Mercaptophenylacetic acid
• Fórmula lineal: HSC₆H₄CH₂CO₂H
• Número de CAS: 39161-84-7
• Peso molecular: 168.21
• Número MDL: MFCD00797617
• Código UNSPSC: 12352100
• ID de la sustancia en PubChem: 24883931
• NACRES: NA.22

Propiedades

• Nivel de calidad: 100
• Ensayo: 97%
• Formulario: solid
• mp: 105-109 °C (lit.)
• grupo funcional: carboxylic acid
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OC(=O)Cc1ccc(S)cc1
• InChI: 1S/C8H8O2S/c9-8(10)5-6-1-3-7(11)4-2-6/h1-4,11H,5H2,(H,9,10)
• Clave InChI: ORXSLDYRYTVAPC-UHFFFAOYSA-N

Descripción

Descripción general

4-Mercaptophenylacetic acid (MPAA), a thiol additive, is widely used in Native Chemical Ligation (NCL) reactions for selective and efficient ligation of peptide fragments.

Aplicación

4-Mercaptophenylacetic acid has been used in the preparation of small ubiquitin-like modifier peptides from bis(2-sulfanylethyl)amido peptide via sequential native chemical ligation.
It can be used:

• On-resin preparation of peptide-^α thiophenylesters which are used in a chemical ligation process for the chemical synthesis of peptides.
• In one pot deprotection of (acetamido-methyl)cysteine following native chemical ligation and/or desulfurization method for the preparation of peptides.
• Palladium facilitated deprotection of N-terminal cysteine through native chemical ligation method for the preparation of synthetically challenging proteins.

Información de seguridad

• Pictogramas: GHS05,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H315,H318,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves