Z0166

α-Zearalenol

• Synonyme(s) : 2,4-Dihydroxy-6-(6α,10-dihydroxy-trans-1-undecenyl)benzoic acid μ-lactone
• Formule empirique (notation de Hill): C₁₈H₂₄O₅
• Numéro CAS: 36455-72-8
• Poids moléculaire : 320.38
• Numéro MDL: MFCD16657008
• Code UNSPSC : 12352200
• ID de substance PubChem : 24902159
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 200
• Forme: powder
• Solubilité: methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• Température de stockage: −20°C
• Chaîne SMILES: C[C@H]1CCC[C@H](O)CCC\C=C\c2cc(O)cc(O)c2C(=O)O1
• InChI: 1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3/b7-3+/t12-,14+/m0/s1
• Clé InChI: FPQFYIAXQDXNOR-QDKLYSGJSA-N
• Informations sur le gène: rat ... Ar(24208)

Description

Application

α-Zearalenol has been used:

• as an analytical standard in the quantification of mycotoxins from animal feed
• to evaluate its oestrogenic activity on boar sperm motility , as an anti-oestrogen control in MCF7 cells
• as a reference standard in a liquid chromatography-negative ion electrospray tandem mass spectrometry with atmospheric pressure chemical ionization (LCAPCI/MS/MS) for bovine follicular fluids (FFs) quantification

Actions biochimiques/physiologiques

α-Zearalenol (α-ZOL) is a catabolite of zearalenone, synthesized majorly in granulosa cells, intestine and liver in pigs. It has estrogenic functionality. α-ZOL inhibits sperm motility in horse possibly by eliciting genotoxic effect. α-ZOL displays higher affinity towards estrogenic receptors.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H314 - H351 - H361fd - H371 - H412
• Conseils de prudence: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Aquatic Chronic 3 - Carc. 2 - Eye Dam. 1 - Repr. 2 - Skin Corr. 1B - STOT SE 2
• Code de la classe de stockage: 8B - Non-combustible, corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges