The minimum purity of this Vinblastine Sulfate product is 96%. The exact purity is lot specific and reported on the product Certificate of Analysis. Maximum limits allowable are also set for several residual solvents and related substances. Total impurities may not exceed 3%. The H2SO4 makes up 10.7% of the purified compound based on the molecular formula: C46H58N4O9 · H2SO4. Please see the link below to access a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/v1377#product-documentation
V1377
Vinblastine sulfate salt
≥97% (HPLC), powder, plant alkaloid
Sinónimos:
VLB, Vincaleukoblastine sulfate salt
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1 MG
$41.000
5 MG
$91.400
10 MG
$165.000
25 MG
$331.000
50 MG
$561.000
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1 MG
$41.000
5 MG
$91.400
10 MG
$165.000
25 MG
$331.000
50 MG
$561.000
About This Item
Fórmula empírica (notación de Hill):
C46H58N4O9 · H2SO4
Número de CAS:
Peso molecular:
909.05
Beilstein:
3659812
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
Nombre del producto
Vinblastine sulfate salt, ≥97% (HPLC)
Nivel de calidad
Ensayo
≥97% (HPLC)
Formulario
(powder or amorphous or crystalline powder)
color
white to light yellow
mp
267 °C (dec.) (lit.)
Absorción
14 at 270 nm in 0.1 M phosphate buffer at 1 mM
16.2 at 259 nm in ethanol at 1 mM
53.7 at 214 nm in ethanol at 1 mM
espectro de actividad antibiótica
neoplastics
Modo de acción
DNA synthesis | interferes
emisor
Eli Lilly
temp. de almacenamiento
2-8°C
cadena SMILES
OS(O)(=O)=O.[H][C@@]12CN(CCc3c([nH]c4ccccc34)[C@@](C1)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC)C[C@](O)(CC)C2
InChI
1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
Clave InChI
KDQAABAKXDWYSZ-PNYVAJAMSA-N
Información sobre el gen
human ... TBCC(6903) , TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)
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Categorías relacionadas
Aplicación
Vinblastine sulfate salt has been used:
- as a microtubule depolymerizing drug for the synchronization of human cell lines in G2/M phase[1]
- as a multidrug resistance screening substrate in human colon cancer cell line (HCT116) cell line[2]
- as an antimicrotubule agent in sub perineural glia of Drosophila brain[3]
Acciones bioquímicas o fisiológicas
Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.
Características y beneficios
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Muta. 2 - Repr. 2
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
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Certificados de análisis (COA)
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Recent studies have shown that paclitaxel leads to activation of Raf-1 kinase and have suggested that this activation is essential for bcl-2 phosphorylation and apoptosis. In the present study, we demonstrate that, in addition to paclitaxel, other agents that interact
Artículos
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What is the composition of vinblastine sulfate salt. I mean what is the ratio of vinblastine: salt in this powder
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