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SML3240

Sigma-Aldrich

CL264

≥98% (HPLC)

Sinónimos:

2-(4-((6-Amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzamido)acetic acid, CL 264, CL-264, N-[4-[[6-Amino-2-(butylamino)-7,8-dihydro-8-oxo-9H-purin-9-yl]methyl]benzoyl]glycine

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About This Item

Fórmula empírica (notación de Hill):
C19H23N7O4
Número de CAS:
1510712-69-2
Peso molecular:
413.43
MDL number:
MFCD32671317
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

General description

CL264 is a hydrophilic molecule. CL264,an adenine analog, is a potent and selective toll-like receptor 7 (TLR7) agonist with no TLR8-stimulating potency. This bioactive small molecule belongs to the category of 9-benzyl-8-hydroxyadenine derivatives. It contains a glycine molecule attached to the benzyl group. Studies show that CL264 is capable of activating NF-κB and stimulating the secretion of IFN-α in cells that express TLR7. CL264 is commonly used at a concentration range from 2 ng/mL to 10 μg/mL for stimulating cells in cultures.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Joseph Skurski et al.
Frontiers in cellular and infection microbiology, 10, 620392-620392 (2021-02-16)
A well-controlled innate immune response is characterized by a rapid yet self-limiting inflammatory response. Although much is known about the range of inflammatory stimuli capable of triggering an innate immune response, the mechanisms which govern the degree of inflammation induced
TLR7 agonist loaded airway epithelial targeting nanoparticles stimulate innate immunity and suppress viral replication in human bronchial epithelial cells
Kan
International Journal of Pharmaceutics, 5, 5:617:121586-5:617:121586 (2022)
Tobias Hilbert et al.
Mediators of inflammation, 2015, 948540-948540 (2016-01-16)
TLR7 ligation in plasmacytoid dendritic cells is promising for the treatment of cancer, allergy, and infectious diseases; however, high doses of ligands are required. We hypothesized that the combination of structurally different TLR7 ligands exponentiates the resulting immune response. CAL-1
Sourav Pal et al.
European journal of medicinal chemistry, 210, 112978-112978 (2020-11-16)
Aberrant activation of the endosomal Toll-like receptor 7 (TLR7) has been implicated in myriad autoimmune diseases and is an established therapeutic target in such conditions. Development of diverse TLR7 antagonists is mainly accomplished through random screening. To correlate human TLR7
Lukas Hatscher et al.
Science signaling, 14(680) (2021-04-29)
The detection of microorganisms and danger signals by pattern recognition receptors on dendritic cells (DCs) and the consequent formation of inflammasomes are pivotal for initiating protective immune responses. Although the activation of inflammasomes leading to secretion of the cytokine IL-1β
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