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M5005

Sigma-Aldrich

Manganese(II) chloride tetrahydrate

BioReagent, suitable for insect cell culture

Sinónimos:

Manganese chloride hydrate, Manganese chloride tetrahydrate, MnCl2.4H2O

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100 G
$59.400
500 G
$160.000

$59.400

Fecha estimada de envío17 de mayo de 2025

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100 G
$59.400
500 G
$160.000

About This Item

Fórmula lineal:
MnCl2 · 4H2O
Número de CAS:
13446-34-9
Peso molecular:
197.91
Número CE:
231-869-6
Número MDL:
MFCD00149792
Código UNSPSC:
12352207
ID de la sustancia en PubChem:
24896966
NACRES:
NA.28

$59.400

Fecha estimada de envío17 de mayo de 2025

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grado

reagent

Línea del producto

BioReagent

Ensayo

≥99% (by AgNO3, titration)

técnicas

cell culture | insect: suitable

mp

58 °C (lit.)

cadena SMILES

Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]

InChI

1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2

Clave InChI

CNFDGXZLMLFIJV-UHFFFAOYSA-L

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Aplicación

Manganese(II) chloride tetrahydrate has been used:
  • as trace element in the fungal complete medium[1]
  • as a supplement in the culture medium for cochlear organotypic culture[2][3]
  • to determine its in vivo antiviral activity against herpes simplex virus-1 (HSV-1), vesicular stomatitis virus (VSV) and vaccinia virus in mice[4]

Acciones bioquímicas o fisiológicas

Manganese is an essential and one of the abundant metal in the tissues of mammals. It plays a key role in the physiological process like development, neuronal function, immune regulation, reproduction, and antioxidant defences. It functions as a cofactor and regulates the activity of the enzymes like oxido-reductases, isomerases, transferases, ligases, lyases and hydrolases It is involved in the innate immunity against viruses.[4]

Palabra de señalización

Danger

Frases de peligro

H301,H318,H373

Clasificaciones de peligro

Acute Tox. 3 Oral - Eye Dam. 1 - STOT RE 2

Órganos de actuación

Brain

Código de clase de almacenamiento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

does not flash

Punto de inflamabilidad (°C)

does not flash

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000429439
0000429439
WXBF4965V
0000363864
0000363865

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Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis
Ding X, et al.
Toxicology Letters, 310, 51-60 (2019)
manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Weilong Wang et al.
Toxicology letters, 279, 77-86 (2017-08-06)
Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including
Xuerui Ding et al.
Toxicology letters, 310, 51-60 (2019-04-17)
Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but
Agrobacterium-mediated transformation of the filamentous fungus Aspergillus awamori.
Michielse CB, et al.
Nature Protocols, 3(10), 1671-1671 (2008)
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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Is it okay to use this reagent on CHO-K1 cells?

    1 answer

    1. This product is use-tested in insect cell culture, not in mammalian cell culture. But it would be the best of the several Manganese(II) chloride tetrahydrate products listed.

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