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Merck

I5528

Sigma-Aldrich

Interferon-Inducible T Cell α Chemoattractant human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinónimos:

β-R1, H174, I-TAC, SCYB9B

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25 μG
$337.000

$337.000


Fecha estimada de envío28 de abril de 2025


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25 μG
$337.000

About This Item

Número MDL:
Código UNSPSC:
51111800
NACRES:
NA.32

$337.000


Fecha estimada de envío28 de abril de 2025


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origen biológico

human

Nivel de calidad

recombinante

expressed in E. coli

Ensayo

≥97% (SDS-PAGE)

Formulario

lyophilized powder

potencia

10-20 ng/mL ED50

mol peso

8.3 kDa

envase

pkg of 25 μg

técnicas

cell culture | mammalian: suitable

impurezas

<0.1ng/mg

Nº de acceso UniProt

temp. de almacenamiento

−20°C

Información sobre el gen

human ... CXCL11(6373)

Acciones bioquímicas o fisiológicas

I-TAC (Interferon-inducible T-cell α chemoattractant) is a chemokine which participates in recruitment of inflammatory cell.[1] It binds to receptor CXCR3 (C-X-C motif chemokine receptor 3). I-TAC is associated with the severity of dengue.[2]

Forma física

Lyophilized in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg of bovine serum albumin.

Nota de análisis

The biological activity is measured by its ability to induce chemotaxis in IL-2 cultured human lymphocytes.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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B P Hoh et al.
Human immunology, 76(6), 421-426 (2015-04-11)
Dengue causes significantly more human disease than any other arboviruses. It causes a spectrum of illness, ranging from mild self-limited fever, to severe and fatal dengue hemorrhagic fever, as evidenced by vascular leakage and multifactorial hemostatic abnormalities. There is no
D P Widney et al.
Journal of immunology (Baltimore, Md. : 1950), 164(12), 6322-6331 (2000-06-08)
A new murine chemokine was identified in a search for glucocorticoid-attenuated response genes induced in the lung during endotoxemia. The first 73 residues of the predicted mature peptide are 71% identical and 93% similar to human CXCL11/IFN-inducible T cell alpha
K E Cole et al.
The Journal of experimental medicine, 187(12), 2009-2021 (1998-06-24)
Chemokines are essential mediators of normal leukocyte trafficking as well as of leukocyte recruitment during inflammation. We describe here a novel non-ELR CXC chemokine identified through sequence analysis of cDNAs derived from cytokine-activated primary human astrocytes. This novel chemokine, referred
M R Rani et al.
The Journal of biological chemistry, 271(37), 22878-22884 (1996-09-13)
We report preliminary characterization of a gene designated beta-R1, which is selectively expressed in response to interferon beta (IFN-beta) compared with IFN-alpha. In human astrocytoma cells, beta-R1 was induced to an equivalent extent by 10 IU/mL IFN-beta or 2500 IU/mL
Y Luo et al.
Journal of neurovirology, 4(6), 575-585 (1999-03-05)
H174 is a new member of the CXC-chemokine family. A cDNA probe containing the entire H174 coding region recognized a predominant inducible transcript of approximately 1.5 kb expressed in interferon (IFN) activated astrocytoma and monocytic cell lines. H174 message can

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