D3630

Diphenhydramine hydrochloride

≥98% (HPLC)

• Sinónimos: 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride
• Fórmula empírica (notación de Hill): C₁₇H₂₁NO · HCl
• Número de CAS: 147-24-0
• Peso molecular: 291.82
• Número CE: 205-687-2
• Número MDL: MFCD00012479
• Código UNSPSC: 12352116
• ID de la sustancia en PubChem: 24277771
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• emisor: Johnson & Johnson
• cadena SMILES: Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2
• InChI: 1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
• Clave InChI: PCHPORCSPXIHLZ-UHFFFAOYSA-N
• Información sobre el gen: human ... HRH1(3269)

Descripción

Aplicación

Diphenhydramine hydrochloride has been used:
as a reference compound to study the long duration of action of antihistamine bilastine in vivo[1]
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation[2] and osteoblasts differentiation[3]
as an antihistamine in experimental studies[4][5]

Acciones bioquímicas o fisiológicas

H1 histamine receptor antagonist
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions.[6][7] It exhibits antimuscarinic and marked sedative effects.[8] DPH is also used to prevent nausea, vomiting and vertigo of various causes.[6] In addition, it acts as a potential therapeutic for insomnia.[7]

Características y beneficios

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves