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C2542

Sigma-Aldrich

Monoclonal Anti-N-Cadherin antibody produced in mouse

clone GC-4, ascites fluid

Sinónimos:

Anti-A-CAM, Anti-A-Cell Adhesion Molecule

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About This Item

Número MDL:
MFCD00164511
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

200

conjugado

unconjugated

forma del anticuerpo

ascites fluid

tipo de anticuerpo

primary antibodies

clon

GC-4, monoclonal

contiene

15 mM sodium azide

reactividad de especies

chicken, mouse, human, rabbit, rat

técnicas

electron microscopy: suitable
immunohistochemistry (frozen sections): 1:100 using chicken cardiac muscle
microarray: suitable
western blot: 1:100 using chicken or rat cardiac muscle

Nº de acceso UniProt

P19022

aplicaciones

research pathology

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)

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Descripción general

N-cadherin is a calcium dependent cell adhesion molecule and is present mainly in cancer cells. Monoclonal anti-N-cadherin antibody reacts with the N-terminal portion of the extracellular domain of adipocyte adhesion molecule (ACAM).

Especificidad

Monoclonal anti-N-cadherin antibody reacts specifically with A-CAM molecule in human, mouse, rabbit, chicken and rat.

Inmunógeno

Affinity purified chicken heart A-CAM.

Aplicación

Monoclonal anti-N-cadherin antibody can be used in immunofluorescent microscopy, electron microscopy and immunoblotting to study the receptor localization of intercellular adherens. It may also be used to study the mechanism of adhesion and interaction in tissues.
Monoclonal anti-N-cadherin antibody can be used in immunohistochemistry (1: 100) and as primary antibody in western blotting (1:1000) .

Acciones bioquímicas o fisiológicas

N-cadherin regulates the Src kinase pathway and also promotes cell motility and invasion. It inhibits adherens junction formation and disrupts existing junctions of cultured lens cells.

Forma física

Monoclonal Anti-N-Cadherin antibody produced in mouse is supplied as ascites fluid containing 15mM sodium azide.

Almacenamiento y estabilidad

For continuous use, store at 2-8 °C for up to one month. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000395438
0000388876
0000335160
0000388876
0000395438

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Visite la Librería de documentos

Balázs Hegedüs et al.
Biophysical journal, 91(7), 2708-2716 (2006-07-11)
Impairment of tissue cohesion and the reorganization of the extracellular matrix are crucial events during the progression toward invasive cell phenotype. We studied the in vitro invasion patterns of nine brain tumor cell lines in three-dimensional collagen gels. Cell-cell and
Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis
Hazan RB
The Journal of cell biology, 148(4), 779-790 (2000)
George Britton et al.
Methods in molecular biology (Clifton, N.J.), 2258, 119-130 (2020-12-20)
In the developing mammalian embryo, intercellular signaling allows cells to self-organize to create spatial patterns of different cell fates. This process is challenging to study because of the difficulty of observing or manipulating embryos on the spatial and temporal scales
C I Marín-Briggiler et al.
International journal of andrology, 33(1), e228-e239 (2009-10-21)
Neural cadherin (N-cadherin) is a transmembrane glycoprotein involved in calcium-dependent cell-cell adhesion and signalling events. The previous evidence shows N-cadherin expression in the human gonads and gametes; however, N-cadherin subcellular localization in human spermatozoa and oocytes, and its involvement in
Kamiel A J Kuijpers et al.
BioMed research international, 2014, 464217-464217 (2014-04-11)
Interstitial cells, also called myofibroblasts, most probably play a major role in the pathogenesis of the overactive bladder. However, no specific phenotypic marker has been identified. We investigated whether N-cadherin could play a role as a discriminatory marker for interstitial
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