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Key Documents

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B5683

Sigma-Aldrich

Betaxolol hydrochloride

>98% (HPLC)

Sinónimos:

SL 75212

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About This Item

Fórmula empírica (notación de Hill):
C18H29NO3 · HCl
Número de CAS:
63659-19-8
Peso molecular:
343.89
EC Number:
264-384-3
MDL number:
MFCD00242959
UNSPSC Code:
12352200
PubChem Substance ID:
24278274
NACRES:
NA.77

assay

>98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: soluble 36 mg/mL

originator

Alcon

SMILES string

Cl[H].CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1

InChI

1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

InChI key

CHDPSNLJFOQTRK-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153)

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Application

Betaxolol hydrochloride has been used as a β1 blocking agent:
  • for the preparation of crystals of (R,S)-betaxolol (BE-IV).
  • to treat mammalian cells prior cell stimulation experiments.
  • to study the solid structure of metoprolol.

Biochem/physiol Actions

Betaxolol hydrochloride has the ability to block calcium channels. Betaxolol is a selective β1 adrenoreceptor antagonist. It has neuroprotective effects on retinal neurons.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Alcon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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I A Latfullin et al.
Klinicheskaia meditsina, 88(2), 68-71 (2010-11-26)
The use of beta-blockers is an important component of therapy of cardiovascular pathology (e.g. coronary heart disease, arterial hypertension) in menopausal women. Comparative data on the efficiency of lokren and carvedilol for the correction of grade 2 AH are presented.
The solid-state structure of the beta-blocker metoprolol: a combined experimental and in silico investigation
Rossi P, et al.
Acta Crystallographica Section C, Structural Chemistry, 75(2) (2019)
Anders Heijl et al.
American journal of ophthalmology, 152(5), 842-848 (2011-08-17)
To analyze reduction of intraocular pressure (IOP) by argon laser trabeculoplasty (ALT) in the Early Manifest Glaucoma Trial and factors influencing the effect of such treatment. Cohort study based on 127 patients from the treatment group of the Early Manifest
J P M Wood et al.
Experimental eye research, 76(4), 505-516 (2003-03-14)
beta-adrenoceptor antagonists are used clinically to reduce elevated intraocular pressure in glaucoma which is characterised by a loss of retinal ganglion cells. Previous studies have shown that the beta(1)-selective adrenoceptor antagonist, betaxolol, is additionally able to protect retinal neurones in
The beta-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol
Wood J P M, et al.
Experimental Eye Research, 76(4) (2003)
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