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Merck

B1557

Sigma-Aldrich

Hyaluronan biotin sodium salt

≥97%, soluble powder

Sinónimos:

Hyaluronic acid biotin

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About This Item

MDL number:
UNSPSC Code:
12352201
NACRES:
NA.25

Quality Level

assay

≥97%

form

soluble powder

mol wt

≥700 kDa

loss

≤5% loss on drying

color

white to tan

storage temp.

2-8°C

Application

Hyaluronan biotin (HA-biotin) may be used as a specific bioaffinity probe to detect HA-binding proteins (hyaladherins), HA-receptors and HA-binding components in tissues and cells. Hyaluronan biotin may be used in the development of affinity binding systems for the immobilization and purification of hyaladherins. HA-biotin may be used in hydrogel development and for drug targeting.
Highly sensitive probe for detecting nanogram levels of hyaluronan binding proteins (hyaladherins).

Other Notes

From cocks comb or fermentation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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D Liu et al.
Frontiers in bioscience : a journal and virtual library, 3, d631-d636 (1998-06-23)
CD44 is a cell surface glycoprotein present on many cell types. Many CD44 isoforms have been identified. All CD44 isoforms utilize identical transmembrane and cytoplasmic domains. The hematopoietic form of CD44 (CD44H) is the major CD44 protein present on normal
T Pouyani et al.
Bioconjugate chemistry, 5(4), 370-372 (1994-07-01)
Hyaluronic acid (HA) is a linear polysaccharide composed of repeating disaccharide units of D-glucuronic acid (GlcUA) and N-acetyl-D-glucosamine (GlcNAc). Hyaluronate plays an important role in many biological processes as mediated by its interactions with a number of HA-binding proteins (the
P Auvinen et al.
The American journal of pathology, 156(2), 529-536 (2000-02-10)
Hyaluronan (HA) is an extracellular matrix polysaccharide that promotes cell migration through its cell surface receptors and by effecting changes in the physical environment. HA expression is frequently increased in malignant tumors, whereas its association with the invasive potential and
Keiko Hasegawa et al.
The Journal of investigative dermatology, 127(7), 1657-1663 (2007-03-17)
Versican interacts with hyaluronan (HA) at its N-terminus and with fibrillin-1 at its C terminus. As versican in the dermis connects microfibrils to the HA-rich matrix for viscoelasticity, dermal diseases may involve destruction of these complexes. A recombinant versican protein
James Melrose et al.
Methods in molecular medicine, 101, 65-78 (2004-08-10)
Hyaluronan (HA) binding proteins (HABPs) were localized in cartilaginous ovine tissues (articular cartilage, intervertebral disc) using a biotinylated HA (bHA) oligosaccharide bioaffinity probe. The bHA oligosaccharide probe was prepared by partial digestion of HA with ovine testicular hyaluronidase, and the

Artículos

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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