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C1700000

Chlorothiazide

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

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About This Item

Fórmula empírica (notación de Hill):
C7H6ClN3O4S2
Número de CAS:
58-94-6
Peso molecular:
295.72
Número MDL:
MFCD00058576
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329774904
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

chlorothiazide

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O

InChI

1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

Clave InChI

JBMKAUGHUNFTOL-UHFFFAOYSA-N

Información sobre el gen

human ... SLC12A3(6559)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

One of the first in the thiazide class of diuretics.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H317,H334

Clasificaciones de peligro

Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Krzysztof J Paluch et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 42(3), 220-229 (2010-12-01)
Chlorothiazide (CTZ) is a poorly soluble diuretic agent. The aim of the present work was to produce and characterise a potassium salt form of chlorothiazide which has the potential advantages of improved aqueous solubility and potassium supplementation. A number of
L P Brion et al.
The Cochrane database of systematic reviews, (1)(1), CD001454-CD001454 (2008-02-07)
Lung edema may complicate respiratory distress syndrome (RDS) in preterm infants. The aim of this review was to assess the risks and benefits of diuretic administration in preterm infants with RDS. The standard search method of the Cochrane Neonatal Review
Krzysztof J Paluch et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 41(5), 603-611 (2010-09-08)
Chlorothiazide (CTZ), unlike other thiazide diuretics, can form salts. An injectable formulation containing the sodium salt is available; however neither the physicochemical characteristics of the salt nor its solid state form have been previously reported. This work reports on the
Charlotte K Leech et al.
Acta crystallographica. Section B, Structural science, 64(Pt 1), 101-107 (2008-01-22)
The compounds chlorothiazide and hydrochlorothiazide (crystalline form II) have been studied in their fully hydrogenous forms by powder neutron diffraction on the GEM diffractometer. The results of joint Rietveld refinement of the structures against multi-bank neutron and single-bank X-ray powder
Saleem Shaikh et al.
Journal of pharmaceutical and biomedical analysis, 48(3), 1055-1057 (2008-09-26)
A simple and precise high performance liquid chromatographic method has been developed and validated for the simultaneous determination of bisoprolol fumarate (BF), and hydrochlorothiazide (HCTZ) in a tablet formulation. Chromatography was carried out at 25 degrees C on a 4.6
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