Myosins are a superfamily of molecular motor proteins found in eukaryotic cells. Motor proteins are involved in muscular contraction, cytokinesis, short-range membrane/vesicle transport and a host of other cellular processes. The myosins are responsible for actin-based motility by using the energy of ATP hydrolysis to generate force and movement along actin filaments. There are many isoforms of myosin of which some have specialized functions in certain cell types (such as muscle), while other isoforms are ubiquitous. Myosin X belongs to a group of myosin isoforms known as unconventional myosins that participate in cellular processes ranging from membrane trafficking to signaling and cell motility. Myosin X is concentrated at the tips of filopodia and Myosin X rich regions travel forward and backward along filopods, (Berg, 2002). It also appears that Myosin X functions in actual filopodia formation, (Bohil, 2006).
Especificidad
Cat. No. AB1094 recognizes human Myosin X.
Predicted to cross react with mouse and rat based on 100% sequence homology. Reactivity with other species has not been tested.
Inmunógeno
Epitope: a.a. 936-953
KLH-conjugated synthetic peptide to amino acids 936-953 of human Myosin X.
Aplicación
Detect Myosin X using this Anti-Myosin X Antibody validated for use in WB.
Calidad
Evaluated on a representative lot by Western blot on human head/neck lysate using Anti-Myosin X.
Descripción de destino
~ 108 kDa
Almacenamiento y estabilidad
Maintain at -20°C for up to 1 year from date of receipt. Upon arrival, aliquot into usable quantities to avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Nota de análisis
Control Human head/neck lysate.
Información legal
GenBank is a registered trademark of United States Department of Health and Human Services
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Certificados de análisis (COA)
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