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475856

Mdivi-1

Name: Mdivi-1
Brand: MM

≥95% (HPLC), dynamin-related GTPases inhibitor, solid

Sinónimos:

Mitochondrial Division Inhibitor, mdivi-1, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor, 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one

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Fórmula empírica (notación de Hill):

C₁₅H₁₀Cl₂N₂O₂S

Número CAS:

338967-87-6

Peso molecular:

353.22

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00974506

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Propiedades

Nombre del producto

Mitochondrial Division Inhibitor, mdivi-1, The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

Sc1[n]([c](c3c(n1)cccc3)=O)c2c(cc(c(c2)OC)Cl)Cl

InChI

1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)

InChI key

NZJKEVWTYMOYOR-UHFFFAOYSA-N

Descripción

General description

A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC₅₀ = 10 and 50 M in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC₅₀<10 M) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.

Packaging

Packaged under inert gas

Other Notes

Cassidy-Stone A., et al. 2008. Dev. Cell14, 193.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Este artículo	454870	M0199	400012
Sigma-Aldrich 475856 Mitochondrial Division Inhibitor, mdivi-1	Sigma-Aldrich 454870 MARK/Par-1 Activity Inhibitor, 39621	Sigma-Aldrich M0199 Mdivi-1	Sigma-Aldrich 400012 Caspase-1 Inhibitor II
description The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.	description The MARK/Par-1 Activity Inhibitor, 39621 controls the biological activity of MARK/Par-1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description ≥98% (HPLC), powder	description The Caspase-1 Inhibitor II, also referenced under CAS 178603-78-6, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.
assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)
form solid	form solid	form powder	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename Calbiochem^®
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility DMSO: 10 mg/mL	solubility DMSO: 100 mg/mL, clear, yellow	solubility DMSO: >20 mg/mL	solubility DMSO: 5 mg/mL

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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