311203

N^G,N^G-Dimethyl-L-arginine, Dihydrochloride

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo.

• Sinónimos: ADMA, 2HCl, N^G,N^G-Dimethyl-L-arginine, Dihydrochloride
• Fórmula empírica (notación de Hill): C₈H₁₈N₄O₂ · 2HCl
• Número de CAS: 220805-22-1
• Peso molecular: 275.18
• Número MDL: MFCD00270857
• Código UNSPSC: 12352209
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (TLC)
• Formulario: amorphous solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 50 mg/mL
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• cadena SMILES: Cl.Cl.N[C@@H](CCCN=C(N(C)C)N)C(=O)O
• InChI: 1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
• Clave InChI: SYLNVYJOPZWPJI-ILKKLZGPSA-N

Descripción

Descripción general

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

Endogenous reversible inhibitor of nitric oxide synthesis in vitro and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
NOS in vitro

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2-3 µM inhibiting nitric oxide synthase in vitro

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Otras notas

Closs, E.I., et al. 1997. Nitric Oxide1, 65.
Faraci, F.M., et al. 1995. Am. J. Physiol.269, H1522.
Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457.
Kotani, K., et al. 1992. J. Neurochem.58, 1127.
Vallance, P., et al. 1992. Lancet339, 572.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable