The product is tested for solubility in water at 50mg/ml. Stock solutions may be stored in aliquots at -20°C for up to 4 months.
N5751
Nω-Nitro-L-arginine methyl ester hydrochloride
≥97% (TLC), powder, nitric oxide production inhibitor
Sinónimos:
L-NAME HCl, L-NAME hydrochloride
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
250 mg | Comprobar disponibilidad del carrito | $21.500 |
1 g | Disponible para enviar HOYdesdePUDAHUEL | $44.600 |
5 g | Comprobar disponibilidad del carrito | $238.000 |
10 g | Comprobar disponibilidad del carrito | $345.000 |
25 g | Disponible para enviar HOYdesdePUDAHUEL | $405.000 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C7H15N5O4 · HCl
Número CAS:
Peso molecular:
269.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
257-116-1
MDL number:
Beilstein/REAXYS Number:
3744166
Assay:
≥97% (TLC)
Form:
powder
Servicio técnico
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Permítanos ayudarleNombre del producto
Nω-Nitro-L-arginine methyl ester hydrochloride, ≥97% (TLC), powder
biological source
synthetic
Quality Segment
assay
≥97% (TLC)
form
powder
color
white to off-white
mp
132 °C
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
InChI
1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChI key
QBNXAGZYLSRPJK-JEDNCBNOSA-N
General description
Nω-Nitro-L-argininemethyl ester hydrochloride or L -NAME HCl, ananalog of arginine, inhibits NO production. It has multiple effects on thevascular system. Inhibits relaxation induced by acetylcholine and induces anincrease in arterial blood pressure. Abolishes lecithinized superoxidedismutase induced vasodilation when used to pretreat aortic ring preparationsof mice. Induces leukocyte adhesion and increases microvascular fluid andprotein fluxes and permeability. It has also been used in many studies oflearning and memory.
Application
Nω-Nitro-L-arginine methyl ester hydrochloride has been used:
- to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons
- to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin
- to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells[1]
- to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat
Biochem/physiol Actions
Arginine analog that inhibits NO production.
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Este artículo | |||
|---|---|---|---|
| assay ≥97% (TLC) | assay ≥98% (TLC) | assay ≥97% (HPLC) | assay ≥98% (TLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level 100 |
| storage temp. −20°C | storage temp. - | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: 50 mg/mL | solubility 1 M HCl: 50 mg/mL, clear, colorless to faintly yellow | solubility water: 50 mg/mL, clear, colorless | solubility water: 50 mg/mL, clear, colorless |
| color white to off-white | color - | color - | color - |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Following reconstitution, what is the recommended storage temperature and how long it will remain stable?
1 answer-
Helpful?
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Is Product N5751, L-NAME hydrochloride, an inhibitor of Nitric Oxide Synthase (NOS)?
1 answer-
L-NAME was described as a reversible, non-specific inhibitor of nitric oxide synthase by Khavandgar. S. et al., Pharmacol. Biochem. Behav., 74, 795 (2003).
Helpful?
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How do I sterilize a prepared solution of Product N5751, L-NAME hydrochloride?
1 answer-
Solutions of this product may be sterile-filtered.
Helpful?
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What is the solution stability of Product N5751, L-NAME hydrochloride?
1 answer-
Although we do not perform solution stability studies, one literature reference recommends keeping solutions on ice during the course of one day.
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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