857130P

18:1 Lyso PA

Avanti Research^™ - A Croda Brand

• Sinónimos: oleoyl lysophosphatidic acid; 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt); PA(18:1(9Z)/0:0); 18:1 LPA; o-LPA; 110681
• Fórmula empírica (notación de Hill): C₂₁H₄₀O₇PNa
• Número de CAS: 325465-93-8
• Peso molecular: 458.50
• Número MDL: MFCD00133427
• Código UNSPSC: 51191904
• NACRES: NA.25

Propiedades

• descripción: 1-oleoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
• Ensayo: >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
• Formulario: powder
• envase: pkg of 1 × 1 g (857130P-1g); pkg of 2 × 100 mg (857130P-200mg); pkg of 1 × 25 mg (857130P-25mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand
• tipo de lípido: cardiolipins; phospholipids
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: O[C@](COP([O-])(O)=O)([H])COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
• InChI: 1S/C21H41O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);/q;+1/p-1/b10-9-;/t20-;/m1./s1
• Clave InChI: XGRLSUFHELJJAB-JGSYTFBMSA-M

Descripción

Descripción general

Lysophosphatidic acid (LPA) belongs to a class of phospholipids, which has a glycerol backbone attached through a phosphate group, an aliphatic chain and a hydroxyl group. The phosphate group is linked to the sn-3 position and the aliphatic chain is linked to either sn-1 or sn-2 position. The hydroxyl group is connected to the remaining sn-1 or sn-2 position.[1]

Aplicación

18:1 Lyso PA or 1-oleoyl-2-hydroxy-sn-glycero-3-phosphate has been used: to study its effects on intracellular calcium concentration [Ca²⁺]i transient in pheochromocytoma cell 12 (PC12) cells and primary astrocytes.[2][3] It has also been used to study its effects on blood glucose level and physical endurance in fasted mice.[4]

Acciones bioquímicas o fisiológicas

Biological responses to LPA: Cell Proliferation, Inhibition of differentiation (neuroblastoma cells, myoblasts), Platelet aggregation, Smooth muscle contraction, Neurotransmitter release, Stress fibre formation/cell rounding/neurite retraction, Cell-surface-fibronectin binding, Tumor cell invasion, Chemotaxis (dictyostelium amoebae), Cl--mediated membrane depolarization (fibroblasts), Inhibition of connexin 43 based cell-cell communication, Increased tight junction permeability (brain endothelial cells). Note: The bioactivity of LPA appears to require long (i.e., C16 to C18) acyl carbon chains of the type usually found associated with membrane lipids although optimum requirements for a single type of acyl carbon chain are not universal. The bioactivity decreases with shorter chain length. In serum, oleoyl and palmitoyl fatty acid containing LPA are the predominant species.

Envase

5 mL Clear Glass Sealed Ampule (857130P-200mg)

5 mL Clear Glass Sealed Ampule (857130P-25mg)

60 mL Amber Wide Mouth Screw Cap Glass Bottle (857130P-1g)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3