857125C

20:4 Lyso PA

1-arachidonoyl-2-hydroxy-sn-glycero-3-phosphate (ammonium salt), chloroform

• Sinónimos: arachidonoyl lysophosphatidic acid; 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate (ammonium salt); PA(20:4(5Z,8Z,11Z,14Z)/0:0); 20:4 LPA
• Fórmula empírica (notación de Hill): C₂₃H₄₂NO₇P
• Número de CAS: 799268-65-8
• Peso molecular: 475.56
• Código UNSPSC: 51191904
• NACRES: NA.25

Propiedades

• Ensayo: >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
• Formulario: liquid
• envase: pkg of 1 × 1 mL (857125C-10mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand 857125C
• concentración: 10 mg/mL (857125C-10mg)
• tipo de lípido: cardiolipins; phospholipids
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: O[C@](COP([O-])(O)=O)([H])COC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O.[NH4+]
• InChI: 1S/C23H39O7P.H3N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(25)29-20-22(24)21-30-31(26,27)28;/h6-7,9-10,12-13,15-16,22,24H,2-5,8,11,14,17-21H2,1H3,(H2,26,27,28);1H3/b7-6-,10-9-,13-12-,16-15-;/t22-;/m1./s1
• Clave InChI: MQNJYFKSBIEJTA-PWZWHAFSSA-N

Descripción

Descripción general

Lysophosphatidic acid (LPA) is a lysophospholipid comprising of glycerol 3-phosphate (G3P), fatty acids, and phosphates.

Aplicación

20:4 Lyso PA (LPA) has been used in feeding low density lipoprotein receptor null (LDLR^-/-) mice. It is suitable for use as standard for high performance liquid chromatography (HPLC) and liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) for the quantification of human plasma LPA, and as a strong agonist for lysophosphatidic acid receptor1(LPA₁).

Acciones bioquímicas o fisiológicas

Lysophosphatidic acid (LPA) is a bioactive lipid produced in tissues. LPA is involved in signal transduction through G-protein coupled receptors. LPA is implicated in many diseases including atherosclerosis, ischaemia perfusion injury, thrombosis and hypertension. LPA also plays an important role in wound healing processes, autoimmune diseases and tumor metastasis.

Envase

5 mL Clear Glass Sealed Ampule (857125C-10mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• Consejos de prudencia: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Órganos de actuación: Central nervous system, Liver,Kidney
• Código de clase de almacenamiento: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): does not flash
• Punto de inflamabilidad (°C): does not flash