910023

3,6,9,12,15,18-Hexaoxahexacos-25-ynoic acid

• Sinónimos: 2-2-2-2-2-2-6 PROTAC^® linker, Alkyne-PEG₆-acid, Bifunctional linker
• Fórmula empírica (notación de Hill): C₂₀H₃₆O₈
• Peso molecular: 404.50
• Código UNSPSC: 12352106

Propiedades

• Formulario: liquid
• idoneidad de la reacción: reagent type: linker
• grupo funcional: alkyne; carboxylic acid
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OC(COCCOCCOCCOCCOCCOCCCCCCC#C)=O

Descripción

Aplicación

This heterobifunctional, PEGylated crosslinker 3,6,9,12,15,18-hexaoxahexacos-25-ynoic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₆-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.

Otras notas

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable