Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals. For research purposes, in animal models or in vitro assays, the prepared solution would require filter sterilization.
347795
Sodium dichloroacetate
98%
Sinónimos:
Dichloroacetic acid sodium salt
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$65.600
50 G
$228.000
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10 G
$65.600
50 G
$228.000
About This Item
Fórmula lineal:
Cl2CHCO2Na
Número de CAS:
Peso molecular:
150.92
EC Number:
MDL number:
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.22
assay:
98%
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Quality Level
assay
98%
impurities
<2% ethyl alcohol
mp
198 °C (dec.) (lit.)
functional group
chloro
SMILES string
[Na+].[O-]C(=O)C(Cl)Cl
InChI
1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1
InChI key
LUPNKHXLFSSUGS-UHFFFAOYSA-M
Gene Information
human ... PDK1(5163) , PDK2(5164) , PDK3(5165) , PDK4(5166)
General description
Application
Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.[4]
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Yongchong Yang et al.
European journal of medicinal chemistry, 45(9), 4300-4306 (2010-07-29)
A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC(50) > 1000 microM for A549). In this paper, a variety of DCA derivatives were synthesized, and
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to
Peng Wang et al.
Shock (Augusta, Ga.), 49(6), 704-711 (2017-08-29)
No pharmacological interventions are currently available to provide neuroprotection for patients suffering from cardiac arrest. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase inhibitor, which activates pyruvate dehydrogenase (PDH), and increases cell adenosine triphosphate (ATP) production by promoting influx of pyruvate
Case report: sodium dichloroacetate (DCA) inhibition of the ?Warburg Effect? in a human cancer patient: complete response in non-Hodgkin?s lymphoma after disease progression with rituximab-CHOP.
Strum SB., et al.
Journal of Bioenergetics and Biomembranes, 45(3), 307-315 (2013)
Frank Comhaire
Medical hypotheses, 120, 65-67 (2018-09-18)
Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic disease the pathogenesis of which remains elusive. Pragmatic proof-of-principle of the hypothetical mechanisms causing the clinical symptoms has been delivered, but it is hard to explain why some patients do respond favourably
Artículos
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
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Is the product sterile and readily soluble in other solution for intravenous use in medical research?
1 answer-
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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I have heard that dichloroacetate has been used for cancer treatment. Is Product 347795, Sodium dichloroacetate, the same chemical?
1 answer-
Some research studies on the use of dichloroacetate as an anti-cancer agent have been performed. At this time, no dichloroacetate compound or product has been approved for use as an anti-cancer drug. The common salts of dichloroacetate are sodium and potassium, and these are what have been used in the research studies. The Sigma-Aldrich products 347795, Sodium Dichloroacetate, and 348082, Potassium Dichloroacetate, are offered for laboratory use only, and are not manufactured or intended for human use.
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How can I make a solution of Product 347795, Sodium dichloroacetate?
1 answer-
Sodium dichloroacetate is soluble in water at 50 mg/ml.
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