296813

Sodium cyanoborohydride solution

1.0 M in THF

• Sinónimos: Sodium borocyanohydride, Sodium cyanoborohydride, Sodium cyanotrihydroborate
• Fórmula lineal: NaBH₃CN
• Número de CAS: 25895-60-7
• Peso molecular: 62.84
• Número MDL: MFCD00003516
• Código UNSPSC: 12352306
• ID de la sustancia en PubChem: 24857879
• NACRES: NA.22

Propiedades

• Nivel de calidad: 200
• idoneidad de la reacción: reagent type: reductant
• concentración: 1.0 M in THF
• solubilidad: THF: soluble(lit.); alcohol: soluble(lit.); hydrocarbons: insoluble(lit.); water: soluble(lit.)
• densidad: 0.915 g/mL at 25 °C
• cadena SMILES: [Na+].[H][B-]([H])([H])C#N
• InChI: 1S/CH3BN.Na/c2-1-3;/h2H3;/q-1;+1
• Clave InChI: CVDUGUOQTVTBJH-UHFFFAOYSA-N

Descripción

Descripción general

Sodium cyanoborohydride is a versatile reducing agent stable in aqueous solution at pH 7.2. It is a weaker reducing agent as compared to NaBH₄. It effectively reduces Schiff bases. NaCNBH₄ participates in the reductive methylation for the efficient and selective conversion of the e-amino groups of lysyl residues in proteins to the mono- and dimethyl derivatives.

Aplicación

Reactant for:

• Direct conversion of heterocyclic aldehydes to esters (oxidizing behavior)
• Reductive amination reactions
• Intramolecular reductive cyclization reactions
• Reductions reactions
• Preparation of dicyanoborate-based ionic liquids as hypergolic fluids for bipropellants

Sodium cyanoborohydride may be used in the following studies:

• As reducing agent for the in vitro radiolabeling of proteins by reductive alkylation.
• Reduction of aldehydes and ketones.
• Selective deoxygenation of aldehydes and ketones.
• Preparation of colloidal gold particles of varying sizes.

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08,GHS05,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H225,H260,H301 + H311 + H331,H314,H335,H336,H351,H410
• Consejos de prudencia: P210 - P231 + P232 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3 - Water-react 1
• Órganos de actuación: Central nervous system, Respiratory system
• Riesgos supl.: EUH019
• Código de clase de almacenamiento: 4.3 - Hazardous materials which set free flammable gases upon contact with water
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): -4.0 °F
• Punto de inflamabilidad (°C): -20 °C