569251-U

Discovery^® HS C18 (3 µm) HPLC Columns

L × I.D. 7.5 cm × 4.6 mm, HPLC Column

• Sinonimo/i: Discovery RP18 HPLC Column
• Codice UNSPSC: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Proprietà

• Nome del prodotto: Colonna HPLC Discovery^® HS C18, 3 μm particle size, L × I.D. 7.5 cm × 4.6 mm
• Materiali: stainless steel column
• Livello qualitativo: 100
• agenzia: suitable for USP L1
• Nome Commerciale: Discovery^®
• Caratteristiche: endcapped
• Produttore/marchio commerciale: Discovery^®
• Confezionamento: 1 ea of
• Grado di funzionalizzazione: 20% Carbon loading
• Parametri: ≤70 °C temp. range; 400 bar pressure (5801 psi)
• tecniche: HPLC: suitable; LC/MS: suitable
• Lungh. × D.I.: 7.5 cm × 4.6 mm
• Area superficiale: 300 m²/g
• Copertura della superficie: 3.2 μmol/m²
• Impurezze: <10 ppm metals
• Matrice: silica gel, high purity, spherical particle platform; fully porous particle
• Gruppo funzionale matrice: C18 (octadecyl) phase
• Dimensione particelle: 3 μm
• Dimensione pori: 120 Å
• Intervallo di pH d’impiego: 2-8
• applicazioni: food and beverages
• Tecnica di separazione: reversed phase

Descrizione

Descrizione generale

Discovery^® HS C18 HPLC column (L × I.D. 7.5 cm × 4.6 mm) is generally found to be stable under acidic and basic conditions.

Applicazioni

• A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies.: This research demonstrates the use of the Discovery^® HS C18 HPLC Column in developing a robust HPLC method for analyzing molnupiravir, showcasing its importance in current pandemic-related pharmaceutical research (Recber et al., 2022).


• A new RP-HPLC method as an auxiliary tool for optimization of sample preparation procedures for tracing of PPCPs of different hydrophilicities.: Highlights the adaptability of the Discovery^® HS C18 HPLC Column in environmental monitoring, specifically for pharmaceutical and personal care products, enhancing analytical methods for environmental safety (Portillo-Castillo et al., 2021).


• Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug-resistant tuberculosis.: This study uses the Discovery^® HS C18 HPLC Column to assess terizidone levels in patient plasma, providing critical insights into the treatment of drug-resistant tuberculosis (Mulubwa and Mugabo, 2018).


• Optimization of LC method for the quantification of doxorubicin in plasma and urine samples in view of pharmacokinetic, biomedical and drug monitoring therapy studies.: Depicts the utility of the Discovery^® HS C18 HPLC Column in optimizing liquid chromatography methods for the potent chemotherapeutic agent doxorubicin, underscoring its role in therapeutic drug monitoring (Maliszewska et al., 2018).


• Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.: Showcases the Discovery^® HS C18 HPLC Column′s application in studying the permeability and transport of efavirenz across the placenta, providing valuable pharmacological insights (Zelena et al., 2017).

Caratteristiche e vantaggi

• Stabile, a bassa perdita per applicazioni LC-MS
• Scalabile dalla colonna analitica alla preparatoria
• Molto stabile per garantire una eccellente riproducibilità da un ciclo all′altro e da un lotto all′altro
• Maggiore idrofobia per una migliore risoluzione degli analiti difficili

   

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Note legali

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable