11019AST
Astec® CHIROBIOTIC® V Chiral (5 μm) HPLC Columns
L × I.D. 15 cm × 2.1 mm, HPLC Column
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About This Item
Codice UNSPSC:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Prodotti consigliati
product name
Colonna HPLC chirale V Astec® CHIROBIOTIC®, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
Materiali
stainless steel column
agenzia
suitable for USP L88
Descrizione
HPLC Column
Nome Commerciale
Astec®
Confezionamento
pkg of 1 ea
Produttore/marchio commerciale
Astec®
Parametri
0-45 °C temperature
241 bar pressure (3500 psi)
tecniche
HPLC: suitable
LC/MS: suitable
Lungh. × D.I.
15 cm × 2.1 mm
Matrice
High-purity silica gel particle platform
fully porous particle
Gruppo funzionale matrice
vancomycin phase
Dimensione particelle
5 μm
Dimensione pori
100 Å
operating pH range
3.5-7.0
Tecnica di separazione
chiral
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Descrizione generale
Astec CHIROBIOTIC® CSPs (chiral stationary phases) interact with ionisable, polar and neutral analytes through multiple molecular interactions. This property makes it widely versatile, thereby making it applicable in a variety of mobile phases. Another feature is the presence of ionic interactions, allowing them to be used reversed-phase and polar ionic modes for sensitive LC-MS operation. CHIROBIOTIC® V is based on bonding Vancomycin which contains 18 chiral centers surrounding three cavities or pockets. These cavities are surrounded with five aromatic rings. Hydrogen acceptor and donor sites are present very near to the ring structures. The CHIROBIOTIC® V is similar to glycoprotein phase′s selectivity wise, with its exception of exhibiting high sample capacity and being stable from 0-100% organic modifier.
Molecole neutre, ammidi, acidi, esteri e ammine esibiscono notevole selettività enantiomerica su queste CSP basate su vancomicina. Un′ampia varietà di ammine secondarie e terziarie sono state separate su CHIROBIOTIC® V in modalità ionica polare. La CHIROBIOTIC® V ha esibito molte delle caratteristiche separative di fasi stazionarie basate su proteine ma con eccezionale stabilità e capacità molto più alta di campionamento. Certi analiti chirali sono stati risolti che non erano stati citati come separati su nessun′altra fase stazionaria. CHIROBIOTIC® V e V2 differiscono nella chimica di legame e nella dimensione dei pori della particella di supporto, presentando quindi selettività e capacità preparative differenti.
- Fase legata: Vancomicina
- Intervallo operativo di pH: 3,5 - 7,0
- Diametro della particella: 5, 10 o 16 μm
- Dimensione dei pori: 100 Å (CHIROBIOTIC® V) o 200 Å (CHIROBIOTIC® V2)
Applicazioni
Chirobiotic V HPLC column may be used for separating the enantiomers of citalopram and its two N-demethylated metabolites, and of the internal standard, alprenolol, in human plasma.
Note legali
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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M Kosel et al.
Journal of chromatography. B, Biomedical sciences and applications, 719(1-2), 234-238 (1998-12-30)
A procedure using a chirobiotic V column is presented which allows separation of the enantiomers of citalopram and its two N-demethylated metabolites, and of the internal standard, alprenolol, in human plasma. Citalopram, demethylcitalopram and didemethylcitalopram, as well as the internal
Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series
Rao, R. Nageswara, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (21), 1911-1916 (2011)
Ana R Ribeiro et al.
Chemosphere, 95, 589-596 (2013-11-05)
Microbial degradation is the most important process to remove organic pollutants in Waste Water Treatment Plants. Regarding chiral compounds this process is normally enantioselective and needs the suitable analytical methodology to follow the removal of both enantiomers in an accurate
Chiral stability-indicating HPLC method for analysis of arotinolol in pharmaceutical formulation and human plasma
Sultan, Maha A., et al.
Arabian Journal of Chemistry, 3 (3), 147-153 (2010)
Hisham Hashem et al.
Journal of chromatography. A, 1218(38), 6727-6731 (2011-08-23)
In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100% ethanol, pH 5.1 was found to give the
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