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Astec® CHIROBIOTIC® T Chiral (5 μm) HPLC Columns

L × I.D. 15 cm × 4.6 mm, HPLC Column

Sinonimo/i:

Chiral Stationary Phase Column T

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About This Item

Codice UNSPSC:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

Colonna HPLC chirale Astec® CHIROBIOTIC® T, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

Materiali

stainless steel column

agenzia

suitable for USP L63

Descrizione

HPLC column

Nome Commerciale

Astec®

Confezionamento

pkg of 1 ea

Produttore/marchio commerciale

Astec®

Parametri

0-45 °C temperature
241 bar pressure (3500 psi)

tecniche

HPLC: suitable
LC/MS: suitable

Lungh. × D.I.

15 cm × 4.6 mm

Matrice

High-purity silica gel particle platform
fully porous particle

Gruppo funzionale matrice

teicoplanin glycopeptide phase

Dimensione particelle

5 μm

Dimensione pori

100 Å

operating pH range

3.8-6.8

Tecnica di separazione

chiral

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Categorie correlate

Descrizione generale

CHIROBIOTIC® T e T2 hanno come selettore chirale la teicoplanina. Offrono una selettività unica per numerose classi di molecole, aminoacidi specificamente non derivatizzati α, β, γ e ciclici, aminoacidi N-derivatizzati, acidi idrossi-carbossilici, composti acidi inclusi gli acidi carbossilici e i fenoli, piccoli peptidi, analiti aromatici neutri e aromatici ciclici e ammine alifatiche. Separazioni che di solito si ottengono su un etere corona chirale o CSP del tipo a scambio di ligandi sono possibili anche sui CHIROBIOTIC® T e T2, ma in fasi mobili molto più semplici, come acqua-alcol. Sono stati inoltre risolti tutti i betabloccanti (amminoalcol) noti e le diidrocumarine. CHIROBIOTIC® T e T2 differiscono nella chimica di legame e nella dimensione dei pori della particella di supporto, presentando quindi selettività e capacità preparative differenti.

  • Fase legata: teicoplanina
  • Intervallo operativo di pH: 3,8 - 6,8
  • Diametro delle particelle: 5, 10 or 16 μm
  • Dimensione dei pori: 100 Å (CHIROBIOTIC® T) o 200 Å (CHIROBIOTIC® T2)

FAQ sui prodotti CHIROBIOTIC
Bibliografia di riferimento sui prodotti CHIROBIOTIC
Articoli sui prodotti chirali

Applicazioni



  • Chiral liquid chromatography-mass spectrometry (LC-MS/MS) method development for the detection of salbutamol in urine samples.: This study details the application of chiral liquid chromatography coupled with mass spectrometry for detecting salbutamol in urine, highlighting the column′s utility in sensitive biomedical assays ( Chan et al., 2016).


  • High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This research demonstrates the column′s effectiveness in enantioseparating specific cyclical amino acids, proving its versatility and importance in chiral separations ( Berkecz et al., 2009).


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Note legali

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

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Certificati d'analisi (COA)

Lot/Batch Number
283822-06
283822-05
283822-04
283822-03
283822-02

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D Abd el-Hady et al.
Journal of pharmaceutical and biomedical analysis, 37(5), 919-925 (2005-05-03)
A simple, sensitive and selective high performance liquid chromatographic method with UV detection for the chiral separation of racemic methotrexate (rac-Mtx) and enantiomeric purity of L-methotrexate in pharmaceutical formulations was developed and validated. The chiral separation was optimized studying both
Berit P Jensen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 865(1-2), 48-54 (2008-03-07)
A stereoselective liquid chromatography-tandem mass spectrometry assay was developed and validated for quantification of S- and R-metoprolol at concentrations of 0.5-50 microg/L in human plasma. Metoprolol was extracted from plasma by liquid-liquid extraction with ethyl acetate (82% recovery). Chromatographic separation
P Jander et al.
Journal of chromatography. A, 919(1), 67-77 (2001-07-19)
The retention behaviour of the enantiomers of underivatized phenylglycine was studied on a Chirobiotic T column packed with amphoteric glycopeptide teicoplanin covalently bonded to the surface of silica gel. The retention and the selectivity of separation of the enantiomers increase
M Sanghvi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 933, 37-43 (2013-07-23)
Due to the lack of sensitivity in current methods for the determination of fenoterol (Fen), a rapid LC-MS/MS method was developed for the determination of (R,R')-Fen and (R,R';S,S')-Fen in plasma and urine. The method was fully validated and was linear
Yuan-Qing Xia et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 788(2), 317-329 (2003-04-23)
An automated online sample extraction method for rat plasma was developed and validated for the quantification of (R)- and (S)-propranolol following the intravenous administration of either the racemate or the individual enantiomers at 5 mg/kg. A dual-column extraction system coupled
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