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V3501

Sigma-Aldrich

Vitamin K1

viscous liquid

Sinonimo/i:

2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K1(20)

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1 G
CHF 151.00
5 G
CHF 562.00
10 G
CHF 885.00

CHF 151.00

Spedizione prevista il14 marzo 2025

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Cambia visualizzazione
1 G
CHF 151.00
5 G
CHF 562.00
10 G
CHF 885.00

About This Item

Formula empirica (notazione di Hill):
C31H46O2
Numero CAS:
84-80-0
Peso molecolare:
450.70
Beilstein:
2568816
Numero CE:
201-564-2
Numero MDL:
MFCD00214063
Codice UNSPSC:
12352205
eCl@ss:
34058015
ID PubChem:
24900741
NACRES:
NA.28

CHF 151.00

Spedizione prevista il14 marzo 2025

Richiedi un ordine bulk

Origine biologica

synthetic (organic
inorganic)

Livello qualitativo

100

Forma fisica

viscous liquid

Colore

, Yellow to Very Dark Yellow to Very Dark Orange

Indice di rifrazione

n20/D 1.527 (lit.)

Punto di fusione

−20 °C (lit.)

Densità

0.984 g/mL at 25 °C (lit.)

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O

InChI

1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
MBWXNTAXLNYFJB-NKFFZRIASA-N

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Categorie correlate

Descrizione generale

Vitamin K1/Phylloquinone is a prenylated naphthoquinone. It is produced by plants, green algae and some species of cyanobacteria.[1]

Applicazioni

Vitamin K1 has been used in the preparation of culture media.[2]

Azioni biochim/fisiol

Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor. Vitamin K1 is essential for blood coagulation, bone and vascular metabolism. Phylloquinone from green leafy vegetables and vegetable oil is the most important dietary source of vitamin K for humans.[1]

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Phytomenadione European Pharmacopoeia (EP) Reference Standard

P1609000

Phytomenadione

Vitamin K1-4a,5,6,7,8,8a-13C6 ≥99 atom % 13C, ≥98% (CP)

Sigma-Aldrich

809888

Vitamin K1-4a,5,6,7,8,8a-13C6

Vitamin K-d7 (5,6,7,8-d4, 2-methyl-d3) 99 atom % D, 97% (CP Sum of E & Z Isomers)

Sigma-Aldrich

705470

Vitamin K-d7 (5,6,7,8-d4, 2-methyl-d3)

Brucella Agar with Hemin and Vitamin K1 suitable for microbiology, NutriSelect® Plus

Millipore

B2926

Brucella Agar with Hemin and Vitamin K1

Emina BioXtra, from Porcine, ≥96.0% (HPLC)

Sigma-Aldrich

51280

Emina

Vitamin K4 ≥98% (HPLC)

Sigma-Aldrich

SMB00580

Vitamin K4

Menaquinone (K2) analytical standard

Supelco

47774

Menaquinone (K2)

Menadione crystalline

Sigma-Aldrich

M5625

Menadione

Phylloquinone (vitamin K1): occurrence, biosynthesis and functions
Basset J G, et al.
Mini-Reviews in Medicinal Chemistry (2017)
Bacteroides disiens sp. nov. and Bacteroides bivius sp. nov. from human clinical infections
Holdeman L V and Johnson J L
International Journal of Systematic and Evolutionary Microbiology (1977)
Beverly Murray et al.
The Journal of antimicrobial chemotherapy, 75(8), 2149-2155 (2020-04-15)
Ibezapolstat (ACX-362E) is the first DNA polymerase IIIC inhibitor undergoing clinical development for the oral treatment of Clostridioides difficile infection (CDI). In this study, the in vitro activity of ibezapolstat was evaluated against a panel of 104 isolates of C.
Ellen M Apalset et al.
Bone, 49(5), 990-995 (2011-08-16)
Evidence of the effect of vitamin K on bone health is conflicting. The aim was to investigate the association between intake of vitamins K1 and K2 and subsequent risk of hip fracture in a general population sample, as well as
Edward P A Gebuis et al.
Haematologica, 96(4), 583-589 (2011-01-05)
Poor anticoagulant stability in patients using vitamin K antagonists is a risk factor for both bleeding and thrombosis. In previous studies supplementation with low dose vitamin K(1) was shown to improve the stability of anticoagulant control. We set up a
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Questions

  1. How much of Vitamin K1 per litre of anaerobic gut-mimicking media is recommended?

    1 answer

    1. This is not an application that is QC tested, but the literature indicates that a good starting point might be 0.5 ug/mL. Please see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658209/

      Another option would be to use a Vitamin K1 ready-made solution, such as: https://www.sigmaaldrich.com/product/sigma/sbr00053

      This product is at a concentration of 5 mg/mL, but recommends dilution down to 1 ug/mL prior to use, and states that the optimal concentration may vary by strain so, further experimentation may be necessary to determine optimal conditions.

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