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Documenti

V9378

Sigma-Aldrich

Vitamin K2

Sinonimo/i:

Menaquinone 4, Menatetrenone

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About This Item

Formula empirica (notazione di Hill):
C31H40O2
Numero CAS:
863-61-6
Peso molecolare:
444.65
Numero MDL:
MFCD00079646
Codice UNSPSC:
12352205
ID PubChem:
329830240
NACRES:
NA.79

Forma fisica

powder

Colore

yellow

Temperatura di conservazione

−20°C

Stringa SMILE

C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC1=C(C)C(=O)c2ccccc2C1=O

InChI

1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+
DKHGMERMDICWDU-GHDNBGIDSA-N

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Applicazioni

  • Vitamin K2 ameliorates osteoarthritis by suppressing ferroptosis and extracellular matrix degradation through activation GPX4′s dual functions.: Vitamin K₂ is shown to have protective effects in osteoarthritis by inhibiting ferroptosis and preventing the degradation of the extracellular matrix. The study emphasizes the therapeutic potential of vitamin K₂ in managing joint health and reducing the progression of osteoarthritis (He et al., 2024).

Azioni biochim/fisiol

Menatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

92210

Timestrip Plus™ 0 °C

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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USP

USP

1381083

Menaquinone-4

Vitamin K4 ≥98% (HPLC)

Sigma-Aldrich

SMB00580

Vitamin K4

Vitamin K2 (MK-9)-(5,6,7,8-d4,2-methyl-d3) ≥98 atom % D, ≥95% (CP)

Sigma-Aldrich

900076

Vitamin K2 (MK-9)-(5,6,7,8-d4,2-methyl-d3)

Phylloquinone (K1) analytical standard

Supelco

47773

Phylloquinone (K1)

Vitamin K2 (MK-9)-4′,5,6,7,8,8′-13C6 ≥99 atom % 13C, ≥95% (CP)

Sigma-Aldrich

900077

Vitamin K2 (MK-9)-4′,5,6,7,8,8′-13C6

Menaquinone -7 Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2363

Menaquinone -7

Vitamin K-d7 (5,6,7,8-d4, 2-methyl-d3) 99 atom % D, 97% (CP Sum of E & Z Isomers)

Sigma-Aldrich

705470

Vitamin K-d7 (5,6,7,8-d4, 2-methyl-d3)

Carla A F Portela et al.
Journal of bacteriology, 196(11), 2012-2022 (2014-03-25)
Oxygen and oxidative stress have become relevant components in clarifying the mechanism that weakens bacterial cells in parallel to the mode of action of bactericidal antibiotics. Given the importance of oxidative stress in the overall defense mechanism of bacteria and
Jonna Weisell et al.
Scientific reports, 11(1), 3014-3014 (2021-02-06)
In calcific aortic valve disease (CAVD) progressive valvular calcification causes aortic valve dysfunction. CAVD has several risk factors such as age and dyslipidemia. Vitamin K was shown to inhibit vascular calcification in mice and valvular calcification in patients with CAVD.
Toshiro Sato et al.
Nutrition journal, 11, 93-93 (2012-11-13)
Vitamin K₂ contributes to bone and cardiovascular health. Therefore, two vitamin K₂ homologues, menaquinone-4 (MK-4) and menaquinone-7 (MK-7), have been used as nutrients by the food industry and as nutritional supplements to support bone and cardiovascular health. However, little is
Katheryne Z Edson et al.
Biochemistry, 52(46), 8276-8285 (2013-10-22)
Vitamin K plays an essential role in many biological processes including blood clotting, maintenance of bone health, and inhibition of arterial calcification. A menaquinone form of vitamin K, MK4, is increasingly recognized for its key roles in mitochondrial electron transport
Renata Tonhosolo et al.
FEBS letters, 584(23), 4761-4768 (2010-11-03)
Herein, we show that intraerythrocytic stages of Plasmodium falciparum have an active pathway for biosynthesis of menaquinone. Kinetic assays confirmed that plasmodial menaquinone acts at least in the electron transport. Similarly to Escherichia coli, we observed increased levels of menaquinone
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