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U2875

Sigma-Aldrich

Uric acid sodium salt

Sinonimo/i:

2,6,8-Trihydroxypurine, Sodium acid urate

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5 G
CHF 125.00
25 G
CHF 487.00
100 G
CHF 1’210.00

CHF 125.00


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Cambia visualizzazione
5 G
CHF 125.00
25 G
CHF 487.00
100 G
CHF 1’210.00

About This Item

Formula condensata:
C5H3N4O3Na
Numero CAS:
Peso molecolare:
190.09
Numero CE:
Numero MDL:
Codice UNSPSC:
41106305
ID PubChem:
NACRES:
NA.51

CHF 125.00


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Origine biologica

microbial
synthetic

Livello qualitativo

Saggio

11.0-13.0% anhydrous basis (Sodium, ICP)

Stato

powder

Solubilità

1 M NaOH: 25 mg/mL, clear, colorless to faintly yellow

Stringa SMILE

[Na].O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3.Na.H/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;;/h(H4,6,7,8,9,10,11,12);;
IHMJZGFANDMEJM-UHFFFAOYSA-N

Applicazioni

Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study.[1] It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.[2]

Azioni biochim/fisiol

Sodium urate is the sodium salt of uric acid. In gout, it is observed in synovial fluid.[3] Sodium urate has been shown to precipitate calcium oxalate from urine.[4] It is also known to reverse the inhibitory effects of reactive oxygen and nitrogen metabolites on gelatinase A activity.[5] Excess sodium urate in soft tissues results in a condition referred to as tophi.[6]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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Certificati d'analisi (COA)

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Kim Gilbert et al.
The journal of trauma and acute care surgery, 86(3), 431-439 (2018-12-07)
Multiple organ failure can develop after hemorrhagic shock (HS). Uric acid (UA) is released from dying cells and can be proinflammatory. We hypothesized that UA could be an alternative mediator of organ apoptosis and inflammation after HS. Ventilated male Wistar
Dissolved urate salts out calcium oxalate in undiluted human urine in vitro: implications for calcium oxalate stone genesis
Grover PK, et al.
Chemistry & Biology, 10(3), 271-278 (2003)
Bin Zhang et al.
Cellular and molecular neurobiology, 37(5), 931-939 (2016-10-07)
Cerebral infarction (CI) is a common clinical cerebrovascular disease, and to explore the pathophysiological mechanisms and seek effective treatment means are the hotspot and difficult point in medical research nowadays. Numerous studies have confirmed that uric acid plays an important
A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog
Toutain PL, et al.
Journal of Veterinary Pharmacology and Therapeutics, 24(1), 43-55 (2001)
Effects of reactive metabolites of oxygen and nitrogen on gelatinase A activity
Owens MW, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 273(2), L445-L450 (1997)

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What's the Grade of this compound?

    1 answer
    1. This is a research grade Uric Acid Sodium Salt.

      Helpful?

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