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T4182

Tyrphostin AG 1478

≥98%, EGFR tyrosine kinase inhibitor, solid

Sinonimo/i:

N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine

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A voi/SKUDisponibilitàPrezzo
1 mg
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CHF 68.90
5 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 227.00
CHF 192.95

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C16H14ClN3O2
Numero CAS:
175178-82-2
Peso molecolare:
315.75
UNSPSC Code:
51111800
PubChem Substance ID:
24278735
NACRES:
NA.77
MDL number:
MFCD00270914
Assay:
≥98%
Form:
solid

CHF 68.90

Per conoscere la disponibilità, visualizza il carrello
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Nome del prodotto

Tyrphostin AG 1478, ≥98%

Quality Segment

100

assay

≥98%

form

solid

solubility

0.1 M HCl: soluble <0.4 mg/mL, DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless, ethanol: soluble 10 mg/mL, methylene chloride: soluble 10 mg/mL, 0.1 M NaOH: insoluble, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble

storage temp.

2-8°C

SMILES string

COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC

InChI

1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)

InChI key

GFNNBHLJANVSQV-UHFFFAOYSA-N

Gene Information

human ... EGFR(1956)
mouse ... Egfr(13649)

Application

Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431.[1]

Biochem/physiol Actions

Selective inhibitor of epidermal growth factor receptor protein
Tyrphostin AG 1478 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It contributes to the development of hypomagnesemia and cardiac dysfunction in rats. Tyrphostin AG 1478 acts as a potential therapeutic agent for breast cancer.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Tyrphostin AG 1478 dissolves in DMSO:MeOH (1:1) at 10 mg/ml to yield a clear, colorless solution. It is also soluble in methylene chloride (10 mg/ml), ethanol (10 mg/ml) and 0.1 N HCl (less than 0.4 mg/ml). However, it is insoluble in water, 2-hydroxypropyl-β-cyclodextrin, and 0.1 N NaOH.

Other Notes

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U103A6566A138
Tyrphostin AG 1478 &#8805;98%

Sigma-Aldrich

T4182

Tyrphostin AG 1478

U-69593 solid

Sigma-Aldrich

U103

U-69593

2-Hydroxysaclofen &#8805;98% (TLC), solid

Sigma-Aldrich

A6566

2-Hydroxysaclofen

Aminobenztropine solid

Sigma-Aldrich

A138

Aminobenztropine

assay

≥98%

assay

-

assay

≥98% (TLC)

assay

-

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

solubility

0.1 M HCl: soluble <0.4 mg/mL, ethanol: soluble 10 mg/mL, 0.1 M NaOH: insoluble, H2O: insoluble, DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless, 2-hydroxypropyl-β-cyclodextrin: insoluble, methylene chloride: soluble 10 mg/mL

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 10 mg/mL, 0.1 M HCl: >40 mg/mL, ethanol: >40 mg/mL, 0.1 M NaOH: insoluble, H2O: insoluble

solubility

H2O: 1 mg/mL, 0.1 M HCl: 1.2 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M NaOH: 9.5 mg/mL

solubility

0.1 M HCl: soluble, 0.1 M NaOH: insoluble, DMSO: soluble, methanol: soluble

Gene Information

human ... EGFR(1956)
mouse ... Egfr(13649)

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
mouse ... Oprk1(18387)
rat ... Oprd1(24613), Oprk1(29335), Oprm1(25601)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

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Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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