T1783

Tobramycin sulfate salt

aminoglycoside antibiotic

• Sinonimo/i: Nebramycin Factor 6 sulfate
• Formula empirica (notazione di Hill): C₁₈H₃₇N₅O₉ · xH₂SO₄
• Peso molecolare: 467.51 (free base basis)
• Numero MDL: MFCD00133864
• Codice UNSPSC: 51281677
• ID PubChem: 329826686
• NACRES: NA.85

Proprietà

• Origine biologica: Streptomyces tenebrarius
• Stato: powder
• Potenza: 634-739 μg per mg
• Condizioni di stoccaggio: (Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.)
• Colore: white to off-white
• Solubilità: H₂O: soluble 50 mg/mL
• Spettro attività antibiotica: Gram-negative bacteria
• Modalità d’azione: protein synthesis | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
• InChI: 1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1; ZEUUPKVZFKBXPW-TWDWGCDDSA-N

Descrizione

Descrizione generale

Chemical structure: aminoglycoside

Applicazioni

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections[1]. Product T1783 has been used to study antibiotic resistance[2].

Azioni biochim/fisiol

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA[2].

Tobramycin sulfate is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

Confezionamento

100MG,500MG

Avvertenza

Hygroscopic

Altre note

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H312 + H332,H360
• Consigli di prudenza: P202 - P261 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges